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[3H]WIN 35,428 bind...
[3H]WIN 35,428 binding in the human brain.
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- Allard, Per (author)
- Umeå universitet,Psykiatri
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Marcusson, J O (author)
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Ross, S B (author)
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(creator_code:org_t)
- 1996
- 1996
- English.
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In: Brain Research. - 0006-8993 .- 1872-6240. ; 706:2, s. 347-50
- Related links:
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https://urn.kb.se/re...
Abstract
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- The binding of [3H]WIN 35,428 was studied in post-mortem human brain, including extrastriatal regions. In the putamen, dopamine almost completely inhibited the [3H]WIN 35,428 binding. Paroxetine inhibited the binding with similar affinity as cocaine, in the range 200-300 nM. In the frontal cortex, [3H]WIN 35,428 labelled cocaine- and alaproclate sensitive binding sites, of which a major fraction was of protein nature. The elucidation of the cocaine sensitive sites in the frontal cortex should be the subject of further research.
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- ref (subject category)
- art (subject category)
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