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Circulating inflamm...
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Clendenen, Tess V
(author)
Circulating inflammation markers and risk of epithelial ovarian cancer.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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American Association for Cancer Research,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-44267
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-44267URI
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https://doi.org/10.1158/1055-9965.EPI-10-1180DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Factors contributing to chronic inflammation appear to be associated with increased risk of ovarian cancer. The purpose of this study was to assess the association between circulating levels of inflammation mediators and subsequent risk of ovarian cancer. Methods: We conducted a case-control study of 230 cases and 432 individually matched controls nested within three prospective cohorts to evaluate the association of prediagnostic circulating levels of inflammation-related biomarkers (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα, IL-1Ra, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1, and sTNF-R2) measured using Luminex xMap technology with risk of ovarian cancer. Results: We observed a trend across quartiles for IL-2 (ORQ4 vs. Q1: 1.57, 95% CI: 0.98–2.52, P = 0.07), IL-4 (ORQ4 vs. Q1: 1.50, 95% CI: 0.95–2.38, P = 0.06), IL-6 (ORQ4 vs. Q1: 1.63, 95% CI: 1.03–2.58, P = 0.03), IL-12p40 (ORQ4 vs. Q1: 1.60, 95% CI: 1.02–2.51, P = 0.06), and IL-13 (ORQ4 vs. Q1: 1.42, 95% CI: 0.90–2.26, P = 0.11). Trends were also observed when cytokines were modeled on the continuous scale for IL-4 (P trend = 0.01), IL-6 (P trend = 0.01), IL-12p40 (P trend = 0.01), and IL-13 (P trend = 0.04). ORs were not materially different after excluding cases diagnosed less than 5 years after blood donation or when limited to serous tumors. Conclusions and Impact: This study provides the first direct evidence that multiple inflammation markers, specifically IL-2, IL-4, IL-6, IL-12, and IL-13, may be associated with risk of epithelial ovarian cancer, and adds to the evidence that inflammation is involved in the development of this disease.
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Koenig, Karen L
(author)
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Berrino, Franco
(author)
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Lukanova, Annekatrin
(author)
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Lokshin, Anna E
(author)
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Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(author)
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Ohlson, NinaUmeå universitet,Patologi,Eva Lundin(Swepub:umu)niaohn95
(author)
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Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
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Krogh, Vittorio
(author)
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Sieri, Sabina
(author)
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Muti, Paola
(author)
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Marrangoni, Adele
(author)
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Nolen, Brian M
(author)
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Liu, Mengling
(author)
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Shore, Roy E
(author)
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Arslan, Alan A
(author)
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Umeå universitetPatologi
(creator_code:org_t)
Related titles
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In:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research20:5, s. 799-8101055-99651538-7755
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Clendenen, Tess ...
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Lundin, Eva
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Zeleniuch-Jacquo ...
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Koenig, Karen L
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Berrino, Franco
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Lukanova, Anneka ...
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Lokshin, Anna E
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Idahl, Annika
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Ohlson, Nina
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Hallmans, Göran
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Krogh, Vittorio
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Sieri, Sabina
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Muti, Paola
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Marrangoni, Adel ...
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Nolen, Brian M
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Liu, Mengling
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Shore, Roy E
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Arslan, Alan A
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Umeå University