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Wegener granulomato...
Wegener granulomatosis in children and young adults. A case study of ten patients.
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Stegmayr, B G (author)
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- Gothefors, Leif (author)
- Umeå universitet,Pediatrik
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Malmer, B (author)
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Müller Wiefel, D E (author)
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Nilsson, K (author)
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- Sundelin, B (author)
- Karolinska Institutet
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2000
- 2000
- English.
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In: Pediatric nephrology (Berlin, West). - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X. ; 14:3, s. 208-13
- Related links:
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- This retrospective study reports seven children and three young adults (aged 11-30 years) who suffered from Wegener granulomatosis. Nine represent consecutive patients admitted to the Division of Nephrology over a period of 23 years. All patients had respiratory tract symptoms and renal involvement on admission. In several patients infiltrates on chest X-ray developed within 2 weeks of onset of symptoms. All patients survived. The median observation period was 9 years (range 13 months to 23 years). One patient progressed to end-stage renal disease. Nine patients initially received cyclophosphamide and steroids. After a median period of 9 months (range 6-31 months) the cyclophosphamide was replaced by azathioprine. Relapses occurred after a median of 28 months (range 4-120 months) in 80% of patients, in six of the eight patients causing a definite decrease in kidney function. We believe that early diagnosis and initiation of therapy reduce the extent of organ damage. Since relapses are frequent, these patients should be evaluated frequently.
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- ref (subject category)
- art (subject category)
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