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Metabolic factors a...
Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Björge, Tone (author)
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Ulmer, Hanno (author)
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- Lindkvist, Björn (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Stocks, Tanja (author)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Engeland, Anders (author)
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Rapp, Kilian (author)
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- Jonsson, Håkan (author)
- Umeå universitet,Onkologi
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Selmer, Randi (author)
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Diem, Guenter (author)
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- Häggström, Christel (author)
- Umeå universitet,Urologi och andrologi
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Tretli, Steinar (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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(creator_code:org_t)
- 2011-03-06
- 2011
- English.
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In: Cancer Causes and Control. - : Springer. - 0957-5243 .- 1573-7225. ; 22:5, s. 743-751
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Objective To investigate metabolic factors and their possible impact on risk of thyroid cancer. Methods A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0 years at baseline were followed for on average 12.0 years. Relative risk of incident thyroid cancer was assessed by levels of BMI, blood pressure, and blood levels of glucose, cholesterol, triglycerides, and by a combined metabolic syndrome (MetS) score. Risk estimates were investigated for quintiles, and a z score distribution of exposures was analyzed using Cox proportional hazards regression. Results During follow-up, 255 women and 133 men were diagnosed with thyroid cancer. In women, there was an inverse association between glucose and thyroid cancer risk, with adjusted RR: 95% CI was 0.61 (0.41–0.90), p trend = 0.02 in the fifth versus the first quintile, and a positive association between BMI and thyroid cancer risk with a significant trend over quintiles. There was no association between the other metabolic factors, single or combined (Met-S), and thyroid cancer. Conclusion In women, BMI was positively, while blood glucose levels were inversely, associated with thyroid cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Thyroid cancer
- Epidemiology
- Metabolic syndrome
- Cohort study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Almquist, Martin
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Johansen, Dorthe
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Björge, Tone
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Ulmer, Hanno
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Lindkvist, Björn
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Stocks, Tanja
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show more...
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Hallmans, Göran
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Engeland, Anders
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Rapp, Kilian
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Jonsson, Håkan
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Selmer, Randi
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Diem, Guenter
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Häggström, Chris ...
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Tretli, Steinar
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Stattin, Pär
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Manjer, Jonas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Causes an ...
- By the university
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Umeå University
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Lund University