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T Cells in Tumors a...
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Wahlin, Björn EngelbrektKarolinska Institutet
(author)
T Cells in Tumors and Blood Predict Outcome in Follicular Lymphoma Treated with Rituximab
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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American Association for Cancer Research,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-45489
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45489URI
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https://doi.org/10.1158/1078-0432.CCR-11-0264DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171129URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122771219URI
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https://gup.ub.gu.se/publication/162122URI
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https://lup.lub.lu.se/record/2056730URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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PURPOSE: T cells influence outcome in follicular lymphoma, but their contributions seem to be modified by therapy. Their impact in patients receiving rituximab without chemotherapy is unknown. EXPERIMENTAL DESIGN: Using flow cytometry, we evaluated the T cells in tumors and/or blood in a total of 250 follicular lymphoma patients included in two Nordic Lymphoma Group randomized trials that compared single rituximab with IFN-α2a-rituximab combinations. RESULTS: In univariate analysis, higher levels of CD3(+), CD4(+), and CD8(+) T cells in both tumors and blood correlated with superior treatment responses, and in multivariate analysis, tumor-CD3(+) (P = 0.011) and blood-CD4(+) (P = 0.029) cells were independent. CD4(+) cells were favorable regardless of treatment arm, but CD8(+) cells were favorable only in patients treated with single rituximab, because IFN-α2a improved responses especially in patients with low CD8(+) cell levels. Higher levels of blood-CD3(+) (P = 0.003) and blood-CD4(+) (P = 0.046) cells predicted longer overall survival, and higher levels of blood-CD8(+) cells longer times to next treatment (P = 0.046). CONCLUSIONS: We conclude that therapeutic effects of rituximab are augmented by tumor-associated T cells for rapid responses and by systemic T cells for sustained responses. CD4(+) and CD8(+) cells are both favorable in patients treated with rituximab. IFN-α2a abrogates the negative impact of few CD8(+) cells.
Subject headings and genre
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Sundström, ChristerUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)chrisund
(author)
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Holte, Harald
(author)
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Hagberg, HansUppsala universitet,Enheten för onkologi(Swepub:uu)hanshagb
(author)
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Erlanson, MartinUmeå universitet,Onkologi(Swepub:umu)maer0058
(author)
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Nilsson-Ehle, Herman,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xnilsh
(author)
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Lindén, OlaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-oli
(author)
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Nordström, Marie
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Ostenstad, Bjørn
(author)
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Geisler, Christian H
(author)
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Brown, Peter de Nully
(author)
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Lehtinen, Tuula
(author)
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Maisenhölder, Martin
(author)
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Tierens, Anne M
(author)
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Sander, BirgittaKarolinska Institutet
(author)
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Christensson, BirgerKarolinska Institutet
(author)
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Kimby, EvaKarolinska Institutet
(author)
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Karolinska InstitutetMolekylär och morfologisk patologi
(creator_code:org_t)
Related titles
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In:Clinical Cancer Research: American Association for Cancer Research17:12, s. 4136-41441078-04321557-3265
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Wahlin, Björn En ...
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Sundström, Chris ...
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Holte, Harald
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Hagberg, Hans
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Erlanson, Martin
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Nilsson-Ehle, He ...
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Lindén, Ola
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Nordström, Marie
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Ostenstad, Bjørn
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Geisler, Christi ...
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Brown, Peter de ...
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Lehtinen, Tuula
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Maisenhölder, Ma ...
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Tierens, Anne M
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Sander, Birgitta
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Christensson, Bi ...
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Kimby, Eva
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Umeå University
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Karolinska Institutet
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Lund University