Search: onr:"swepub:oai:DiVA.org:umu-45507" >
Evolution and class...
Evolution and classification of the CRISPR-Cas systems
-
Makarova, Kira S (author)
-
Haft, Daniel H (author)
-
Barrangou, Rodolphe (author)
-
show more...
-
Brouns, Stan J J (author)
-
- Charpentier, Emmanuelle (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Charpentier
-
Horvath, Philippe (author)
-
Moineau, Sylvain (author)
-
Mojica, Francisco J M (author)
-
Wolf, Yuri I (author)
-
Yakunin, Alexander F (author)
-
van der Oost, John (author)
-
Koonin, Eugene V (author)
-
show less...
-
(creator_code:org_t)
- 2011-05-09
- 2011
- English.
-
In: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 9:6, s. 467-477
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique spacer content. Here, we provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the extremely dynamic evolution of the CRISPR-Cas systems, a unified classification of these systems should be based on multiple criteria. Accordingly, we propose a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of the CRISPR repeats and the architecture of the CRISPR-cas loci.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Makarova, Kira S
-
Haft, Daniel H
-
Barrangou, Rodol ...
-
Brouns, Stan J J
-
Charpentier, Emm ...
-
Horvath, Philipp ...
-
show more...
-
Moineau, Sylvain
-
Mojica, Francisc ...
-
Wolf, Yuri I
-
Yakunin, Alexand ...
-
van der Oost, Jo ...
-
Koonin, Eugene V
-
show less...
- Articles in the publication
-
Nature Reviews M ...
- By the university
-
Umeå University