Search: onr:"swepub:oai:DiVA.org:umu-45885" >
Total zinc intake m...
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Kanoni, Stavroula
(author)
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant : a 14-cohort meta-analysis
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-08-20
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Alexandria :American diabetes association,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-45885
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45885URI
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https://doi.org/10.2337/db11-0176DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159243URI
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https://lup.lub.lu.se/record/2187044URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123196380URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants.RESEARCH DESIGN AND METHODS We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes.RESULTS We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant.CONCLUSIONS Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Nettleton, Jennifer A
(author)
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Hivert, Marie-France
(author)
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Ye, Zheng
(author)
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van Rooij, Frank JA
(author)
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Shungin, DmitryLund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Department of Clinical Sciences, Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-dsn
(author)
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Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-eso
(author)
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Ngwa, Julius S
(author)
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Wojczynski, Mary K
(author)
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Lemaitre, Rozenn N
(author)
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Gustafsson, Stefan
(author)
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Anderson, Jennifer S
(author)
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Tanaka, Toshiko
(author)
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Hindy, GeorgeLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ghu
(author)
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Saylor, Georgia
(author)
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Renström, FridaUmeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts(Swepub:umu)frre0001
(author)
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Bennett, Amanda J
(author)
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van Duijn, Cornelia M
(author)
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Florez, Jose C
(author)
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Fox, Caroline S
(author)
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Hofman, Albert
(author)
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Hoogeveen, Ron C
(author)
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Houston, Denise K
(author)
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Hu, Frank B
(author)
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Franks, PaulLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(author)
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Johansson, IngegerdUmeå universitet,Institutionen för odontologi(Swepub:umu)injo0003
(author)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)larslind
(author)
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Liu, Yongmei
(author)
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McKeown, Nicola
(author)
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Ordovas, Jose
(author)
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Pankow, James S
(author)
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Sijbrands, Eric JG
(author)
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva
(author)
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Uitterlinden, André G
(author)
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Yannakoulia, Mary
(author)
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Zillikens, M Carola
(author)
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Wareham, Nick J
(author)
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Prokopenko, Inga
(author)
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Bandinelli, Stefania
(author)
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Forouhi, Nita G
(author)
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Cupples, L Adrienne
(author)
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Loos, Ruth J
(author)
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Hallmans, GöranUmeå universitet,Näringsforskning,Medicin(Swepub:umu)goha0001
(author)
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Dupuis, Josée
(author)
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Langenberg, Claudia
(author)
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Ferrucci, Luigi
(author)
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Kritchevsky, Stephen B
(author)
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McCarthy, Mark I
(author)
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Ingelsson, ErikKarolinska Institutet
(author)
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Borecki, Ingrid B
(author)
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Witteman, Jacqueline CM
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Siscovick, David S
(author)
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Meigs, James B
(author)
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Franks, Paul WUmeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts(Swepub:umu)pafr0003
(author)
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Dedoussis, George V
(author)
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Umeå universitetMedicin
(creator_code:org_t)
Related titles
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In:DiabetesAlexandria : American diabetes association60:9, s. 2407-24160012-17971939-327X
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Diabetes
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Kanoni, Stavroul ...
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Nettleton, Jenni ...
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Hivert, Marie-Fr ...
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Ye, Zheng
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van Rooij, Frank ...
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Shungin, Dmitry
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Sonestedt, Emily
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Ngwa, Julius S
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Wojczynski, Mary ...
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Lemaitre, Rozenn ...
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Gustafsson, Stef ...
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Anderson, Jennif ...
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Tanaka, Toshiko
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Hindy, George
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Saylor, Georgia
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Renström, Frida
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Bennett, Amanda ...
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van Duijn, Corne ...
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Florez, Jose C
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Fox, Caroline S
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Hofman, Albert
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Hoogeveen, Ron C
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Houston, Denise ...
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Hu, Frank B
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Franks, Paul
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Johansson, Ingeg ...
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Lind, Lars
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Liu, Yongmei
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McKeown, Nicola
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Ordovas, Jose
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Pankow, James S
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Sijbrands, Eric ...
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Syvänen, Ann-Chr ...
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Uitterlinden, An ...
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Yannakoulia, Mar ...
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Zillikens, M Car ...
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Wareham, Nick J
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Prokopenko, Inga
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Bandinelli, Stef ...
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Forouhi, Nita G
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Cupples, L Adrie ...
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Loos, Ruth J
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Hallmans, Göran
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Dupuis, Josée
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Langenberg, Clau ...
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Ferrucci, Luigi
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Kritchevsky, Ste ...
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McCarthy, Mark I
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Ingelsson, Erik
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Borecki, Ingrid ...
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Witteman, Jacque ...
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Orho-Melander, M ...
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Siscovick, David ...
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Meigs, James B
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Franks, Paul W
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Dedoussis, Georg ...
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Diabetes
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Umeå University
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Uppsala University
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Lund University
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Karolinska Institutet