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p63 transcriptional...
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Boldrup, LindaUmeå universitet,Patologi,Karin Nylander
(author)
p63 transcriptionally regulates BNC1, a Pol I and Pol II transcription factor that regulates ribosomal biogenesis and epithelial differentiation
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Elsevier,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-45966
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45966URI
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https://doi.org/10.1016/j.ejca.2011.06.032DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The p53-family member, p63 is a transcription factor that influences cellular adhesion, motility, proliferation, survival and apoptosis, and has a major role in regulating epithelial stem cells. Expression of p63 is often dysregulated in squamous cell carcinomas of the head and neck. In this study we show that p63 induces the expression of the basal epithelial transcription factor, Basonuclin 1. Basonuclin 1 is an unusual transcription factor that interacts with a subset of promoters of genes that are transcribed by both RNA polymerase-I and -II and has roles in maintaining ribosomal biogenesis and the proliferative potential of immature epithelial cells. Chromatin immunoprecipitation and reporter assays demonstrate that Basonuclin 1 is a direct transcriptional target of p63 and we also show that up-regulation of Basonuclin 1 is a common event in squamous cell carcinomas of the head and neck. These data identify a new transcriptional programme mediated by p63 regulation of the Basonuclin 1 transcription factor in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Coates, Philip J
(author)
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Laurell, GöranUmeå universitet,Öron- näs- och halssjukdomar(Swepub:umu)gala0001
(author)
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Nylander, KarinUmeå universitet,Patologi(Swepub:umu)kaanyr77
(author)
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Umeå universitetPatologi
(creator_code:org_t)
Related titles
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In:European Journal of Cancer: Elsevier48:9, s. 1401-14060959-80491879-0852
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