Sökning: onr:"swepub:oai:DiVA.org:umu-45966" > p63 transcriptional...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03190naa a2200445 4500 | |
001 | oai:DiVA.org:umu-45966 | |
003 | SwePub | |
008 | 110824s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-459662 URI |
024 | 7 | a https://doi.org/10.1016/j.ejca.2011.06.0322 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boldrup, Lindau Umeå universitet,Patologi,Karin Nylander4 aut0 (Swepub:umu)liabop98 |
245 | 1 0 | a p63 transcriptionally regulates BNC1, a Pol I and Pol II transcription factor that regulates ribosomal biogenesis and epithelial differentiation |
264 | 1 | b Elsevier,c 2012 |
338 | a print2 rdacarrier | |
520 | a The p53-family member, p63 is a transcription factor that influences cellular adhesion, motility, proliferation, survival and apoptosis, and has a major role in regulating epithelial stem cells. Expression of p63 is often dysregulated in squamous cell carcinomas of the head and neck. In this study we show that p63 induces the expression of the basal epithelial transcription factor, Basonuclin 1. Basonuclin 1 is an unusual transcription factor that interacts with a subset of promoters of genes that are transcribed by both RNA polymerase-I and -II and has roles in maintaining ribosomal biogenesis and the proliferative potential of immature epithelial cells. Chromatin immunoprecipitation and reporter assays demonstrate that Basonuclin 1 is a direct transcriptional target of p63 and we also show that up-regulation of Basonuclin 1 is a common event in squamous cell carcinomas of the head and neck. These data identify a new transcriptional programme mediated by p63 regulation of the Basonuclin 1 transcription factor in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a p63 | |
653 | a BNC1 | |
653 | a Epithelium | |
653 | a Differentiation | |
653 | a Ribosome synthesis | |
653 | a RNA polymerase I | |
653 | a Squamous cell carcinoma | |
653 | a Oncology | |
653 | a onkologi | |
700 | 1 | a Coates, Philip J4 aut |
700 | 1 | a Laurell, Göranu Umeå universitet,Öron- näs- och halssjukdomar4 aut0 (Swepub:umu)gala0001 |
700 | 1 | a Nylander, Karinu Umeå universitet,Patologi4 aut0 (Swepub:umu)kaanyr77 |
710 | 2 | a Umeå universitetb Patologi4 org |
773 | 0 | t European Journal of Cancerd : Elsevierg 48:9, s. 1401-1406q 48:9<1401-1406x 0959-8049x 1879-0852 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45966 |
856 | 4 8 | u https://doi.org/10.1016/j.ejca.2011.06.032 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.