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A little bit of sugar makes polycomb better
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- Schwartz, Yuri B (author)
- Department of Molecular Biology and Biochemistry, Rutgers University, New Jersey U.S.A.
- Pirrotta, Vincenzo (author)
- Department of Molecular Biology and Biochemistry, Rutgers University, New Jersey US.A. (creator_code:org_t)
- 2009-08-11
- 2009
- English.
- In: Journal of molecular cell biology. - : Oxford University Press (OUP). - 1759-4685 .- 1674-2788. ; 1:1, s. 11-12
- Journal article (peer-reviewed)
Abstract
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- Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.
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