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[Polycomb and trith...
[Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].
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- Shwartz, Yuri B (author)
- Rutgers University, New Jersey, U.S.A.
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- Kahn, Tatiana G (author)
- Rutgers University, New Jersey, U.S.A.
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Pirrotta, V (author)
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Rutgers University, New Jersey, US.A. (creator_code:org_t)
- 2010
- 2010
- Russian.
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In: Journal Genetika. - 0016-6758. ; 46:10, s. 1413-1416
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genome analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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