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A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits

Nissan, Tracy A (author)
Biochemie-Zentrum der Universität Heidelberg
Galani, Kyriaki (author)
Maco, Bohumil (author)
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Tollervey, David (author)
Aebi, Ueli (author)
Hurt, Ed (author)
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 (creator_code:org_t)
Elsevier BV, 2004
2004
English.
In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 15:2, s. 295-301
  • Journal article (peer-reviewed)
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  • Analyses of isolated pre-ribosomes yielded biochemical "snapshots" of the dynamic, nascent 60S and 40S subunits during their path from the nucleolus to the cytoplasm. Here, we present the structure of a pre-60S ribosomal intermediate located in the nucleoplasm. A huge dynein-related AAA-type ATPase (Rea1) and the Rix1 complex (Rix1-Ipi1-Ipi3) are components of an extended (approximately 45 nm long) pre-60S particle. Antibody crosslinking in combination with electron microscopy revealed that the Rea1 localizes to the "tail" region and ribosomal proteins to the "head" region of the elongated "tadpole-like" structure. Furthermore, in vitro treatment with ATP induces dissociation of Rea1 from the pre-60S subunits. Rea1 and the Rix1 complex could mediate ATP-dependent remodeling of 60S subunits and subsequent export from the nucleoplasm to the cytoplasm.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

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Nissan, Tracy A
Galani, Kyriaki
Maco, Bohumil
Tollervey, David
Aebi, Ueli
Hurt, Ed
About the subject
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Biochemistry and ...
Articles in the publication
Molecular Cell
By the university
Umeå University

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