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Novel reporter mous...
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.
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Lienenklaus, Stefan (author)
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Cornitescu, Marius (author)
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Zietara, Natalia (author)
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Łyszkiewicz, Marcin (author)
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- Gekara, Nelson (author)
- Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
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Jabłónska, Jadwiga (author)
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Edenhofer, Frank (author)
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Rajewsky, Klaus (author)
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Bruder, Dunja (author)
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Hafner, Martin (author)
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Staeheli, Peter (author)
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Weiss, Siegfried (author)
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(creator_code:org_t)
- The American Association of Immunologists, 2009
- 2009
- English.
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 183:5, s. 3229-3236
- Related links:
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http://www.jimmunol....
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
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- Type I IFN is a major player in innate and adaptive immune responses. Besides, it is involved in organogenesis and tumor development. Generally, IFN responses are amplified by an autocrine loop with IFN-beta as the priming cytokine. However, due to the lack of sensitive detection systems, where and how type I IFN is produced in vivo is still poorly understood. In this study, we describe a luciferase reporter mouse, which allows tracking of IFN-beta gene induction in vivo. Using this reporter mouse, we reveal strong tissue-specific induction of IFN-beta following infection with influenza or La Crosse virus. Importantly, this reporter mouse also allowed us to visualize that IFN-beta is expressed constitutively in several tissues. As suggested before, low amounts of constitutively produced IFN might maintain immune cells in an activated state ready for a timely response to pathogens. Interestingly, thymic epithelial cells were the major source of IFN-beta under noninflammatory conditions. This relatively high constitutive expression was controlled by the NF Aire and might influence induction of tolerance or T cell development.
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- art (subject category)
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- By the author/editor
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Lienenklaus, Ste ...
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Cornitescu, Mari ...
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Zietara, Natalia
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Łyszkiewicz, Mar ...
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Gekara, Nelson
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Jabłónska, Jadwi ...
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show more...
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Edenhofer, Frank
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Rajewsky, Klaus
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Bruder, Dunja
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Hafner, Martin
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Staeheli, Peter
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Weiss, Siegfried
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show less...
- Articles in the publication
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Journal of Immun ...
- By the university
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Umeå University