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  • Chuang, Shu-Chun (author)

A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Oxford :Pergamon,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-48312
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-48312URI
  • https://doi.org/10.1016/j.ejca.2011.02.007DOI
  • https://lup.lub.lu.se/record/2179906URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123270437URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (+/- 1 year), date (+/- 1 year) and time (+/- 3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate <= 5, 5-10, 10-15 (reference), 15-20, and > 20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity < 0.01). Our results suggest a U-shaped association between plasma folate and pancreatic cancer risk in both men and women. The positive association that we observed between methionine and pancreatic cancer may be sex dependent and may differ by time of follow-up. However, the mechanisms behind the observed associations warrant further investigation.

Subject headings and genre

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  • Stolzenberg-Solomon, Rachael (author)
  • Ueland, Per Magne (author)
  • Vollset, Stein Emil (author)
  • Midttun, Oivind (author)
  • Olsen, Anja (author)
  • Tjonneland, Anne (author)
  • Overvad, Kim (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Morois, Sophie (author)
  • Clavel-Chapelon, Francoise (author)
  • Teucher, Birgit (author)
  • Kaaks, Rudolf (author)
  • Weikert, Cornelia (author)
  • Boeing, Heiner (author)
  • Trichopoulou, Antonia (author)
  • Benetou, Vassiliki (author)
  • Naska, Androniki (author)
  • Jenab, Mazda (author)
  • Slimani, Nadia (author)
  • Romieu, Isabelle (author)
  • Michaud, Dominique S. (author)
  • Palli, Domenico (author)
  • Sieri, Sabina (author)
  • Panico, Salvatore (author)
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  • Duell, Eric J. (author)
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  • Molina-Montes, Esther (author)
  • Maria Huerta, Jose (author)
  • Larranaga, Nerea (author)
  • Barricarte Gurrea, Aurelio (author)
  • Johansen, DortheLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kirm-djo (author)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (author)
  • Ye, WeiminKarolinska Institutet (author)
  • Sund, Malin,1972-Umeå universitet,Kirurgi,Malin Sund(Swepub:umu)masu0021 (author)
  • Peeters, Petra H. M. (author)
  • Jeurnink, Suzanne (author)
  • Wareham, Nicholas (author)
  • Khaw, Kay-Tee (author)
  • Crowe, Francesca (author)
  • Riboli, Elio (author)
  • Bueno-de-Mesquita, Bas (author)
  • Vineis, Paolo (author)
  • KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:European Journal of CancerOxford : Pergamon47:12, s. 1808-18160959-80491879-0852

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