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Association of adip...
Association of adipose tissue blood flow with fat depot sizes and adipokines in women
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- Andersson, Jonas (author)
- Umeå universitet,Medicin
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- Karpe, Fredrik (author)
- NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK
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- Sjöström, Lars-Göran (author)
- Umeå universitet,Medicin
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- Riklund, Katrine (author)
- Umeå universitet,Diagnostisk radiologi
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
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- Olsson, Tommy (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2011-07-26
- 2012
- English.
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In: International Journal of Obesity. - : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 36:6, s. 783-789
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. International Journal of Obesity advance online publication, 26 July 2011; doi:10.1038/ijo.2011.152.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- adipose tissue
- blood flow
- body fat distribution
- leptin
- women
- medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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