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Cytoskeletal filame...
Cytoskeletal filament systems : assembly, regulation, and interplay in mammalian cells
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- Sellin, Mikael E, 1979- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Martin Gullberg,Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Gullberg, Martin, Professor (thesis advisor)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Thorner, Jeremy, Professor (opponent)
- University of California Berkeley, Department of Molecular and Cell Biology
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(creator_code:org_t)
- ISBN 9789174593013
- Umeå : Umeå universitet, Institutionen för molekylärbiologi, 2011
- English 68 s.
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Series: Umeå University medical dissertations, 0346-6612 ; 1450
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Abstract
Subject headings
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- The cell represents the basic unit of structure and function for all life. The interior of a eukaryotic cell is organized by an extensive array of protein filaments – collectively referred to as the cytoskeleton. These filaments serve diverse essential functions, e.g. to provide mechanical resilience, facilitate intracellular transport, and enable cell polarization, locomotion and division. Here I have explored the mechanisms that regulate synthesis and assembly of two cytoskeletal filament systems – microtubules and septins – and how these interact in human cells. The present thesis is based on three principal discoveries. Firstly, we have found that the microtubule-destabilizing protein Op18/Stathmin also regulates synthesis of tubulin heterodimers, which are the building blocks for microtubules. Secondly, we have unraveled the general rules that govern assembly of mammalian septins into native polymerization-competent heterooligomers. Finally, our combined results point to a non-reciprocal interplay whereby interphase microtubules support a disc-like arrangement of septin filaments, which delineate static plasma membrane regions. I here discuss the physiological significance and implications of these findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- cell research
- cellforskning
Publication and Content Type
- vet (subject category)
- dok (subject category)
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