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Insulin-like growth...
Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer : a nested case-control study
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Toriola, Adetunji T. (author)
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Surcel, Helja-Marja (author)
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Schock, Helena (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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Pukkala, Eero (author)
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Chen, Tianhui (author)
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Toniolo, Paolo (author)
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Lehtinen, Matti (author)
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Zeleniuch-Jacquotte, Anne (author)
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Lukanova, Annekatrin (author)
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(creator_code:org_t)
- 2011-08-11
- 2011
- English.
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In: Cancer Causes and Control. - : Springer Netherlands. - 0957-5243 .- 1573-7225. ; 22:11, s. 1607-1611
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Insulin-like growth factor (IGF-I)
- C-reactive protein (CRP)
- Pregnancy
- Non-epithelial ovarian cancer
- Nested case-control study
Publication and Content Type
- ref (subject category)
- art (subject category)
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Toriola, Adetunj ...
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Surcel, Helja-Ma ...
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Lundin, Eva
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Schock, Helena
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Grankvist, Kjell
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Pukkala, Eero
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show more...
-
Chen, Tianhui
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Toniolo, Paolo
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Lehtinen, Matti
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Zeleniuch-Jacquo ...
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Lukanova, Anneka ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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Cancer Causes an ...
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Umeå University