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Altered expression ...
Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus
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- Danielsson, Karin (author)
- Umeå universitet,Institutionen för odontologi,Institutionen för medicinsk biovetenskap
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- Wahlin, Ylva-Britt (author)
- Umeå universitet,Institutionen för odontologi
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- Gu, Xiaolian (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Karin Nylander
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- Boldrup, Linda (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Karin Nylander
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- Nylander, Karin (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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(creator_code:org_t)
- 2011-09-22
- 2012
- English.
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In: Journal of Oral Pathology & Medicine. - : Wiley. - 0904-2512 .- 1600-0714. ; 41:1, s. 90-95
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Oral lichen planus (OLP), which is a chronic inflammatory disease of the oral mucosa with unknown etiology, affects about 2% of the population. MicroRNAs are small non-coding RNAs involved in normal processes such as development and differentiation as well as progression of human diseases. The aim of this study was to investigate the expression of miR-21, miR-125b, and miR-203 and to compare RNA levels of their potential targets, the tumor suppressor p53 and its relative p63, both known to be deregulated in OLP. Methods: In biopsies from 20 patients with OLP and 20 age- and sex-matched healthy controls, epithelium was laser dissected and analyzed for the expression of miR-21, miR-125b, miR-203, p53, and p63 using qRT/PCR. Results: Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and ΔNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between ΔNp63 and miR-203 and between miR-21 and p53, respectively. Conclusion: Results indicate a role for the studied microRNAs in changes seen in OLP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- miR-125b;miR-203;miR-21;oral lichen planus
- odontologi
- Odontology
- Pathology
- patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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