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- Berglund, Staffan,1975-Umeå universitet,Pediatrik (author)
Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants
- Article/chapterEnglish2011
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- American Society for Nutrition,2011
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- LIBRIS-ID:oai:DiVA.org:umu-49774
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49774URI
- https://doi.org/10.3945/ajcn.111.013938DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123632556URI
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- Language:English
- Summary in:English
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- BACKGROUND: The iron-regulatory hormone hepcidin has not been studied in infants, who experience large physiologic changes in iron status. OBJECTIVE: The objective was to study hepcidin and erythropoietin and their correlation with iron status in iron-replete and iron-deficient low-birth-weight (LBW) infants-a group at particular risk of iron deficiency (ID). DESIGN: We randomly assigned 285 otherwise healthy LBW infants to receive, from 6 wk to 6 mo of age, 3 doses of iron supplements: 0 (placebo), 1, or 2 mg/kg daily. Hepcidin, erythropoietin, hemoglobin, and variables of iron status were analyzed. RESULTS: Serum hepcidin did not change over time in the placebo group, despite a rapid decrease in serum ferritin. In iron-supplemented infants, hepcidin increased significantly, reaching a mean (±SD) concentration of 19.2 ± 2.5 ng/mL in the 2-mg/kg group compared with 13.0 ± 2.6 ng/mL in the placebo group at age 6 mo (P < 0.001). The difference was even larger between iron-deficient and iron-replete infants. Hepcidin was independently positively correlated with ferritin at all ages and was negatively correlated with the transferrin receptor concentration at age 6 wk and with transferrin at age 6 mo. Erythropoietin was initially similar between groups but decreased significantly in iron-supplemented infants. In addition to being negatively correlated with hemoglobin, it was also independently negatively correlated with indicators of iron status. CONCLUSIONS: Hepcidin is closely associated with iron status and may be a useful indicator of iron stores and ID in infants. Erythropoietin is negatively correlated with iron status, which suggests a feedback mechanism that needs further study. This trial is registered at clinicaltrials.gov as NCT00558454.
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- Lönnerdal, BoThe Department of Nutrition, University of California, Davis, CA, USA (author)
- Westrup, BjörnKarolinska Institutet (author)
- Domellöf, MagnusUmeå universitet,Pediatrik(Swepub:umu)mado0002 (author)
- Umeå universitetPediatrik (creator_code:org_t)
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- In:American Journal of Clinical Nutrition: American Society for Nutrition94:6, s. 1553-15610002-91651938-3207
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