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Persistence of cell...
Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of Francisella tularensis
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- Eneslätt, Kjell (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Rietz, Cecilia (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Rydén, Patrik (författare)
- Umeå universitet,Institutionen för matematik och matematisk statistik,Computational Life Science Cluster (CLiC)
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- Stöven, Svenja (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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House, Robert V (författare)
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Wolfraim, Lawrence A (författare)
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- Tärnvik, Arne (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Sjöstedt, Anders (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Arcum
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(creator_code:org_t)
- 2011-02-21
- 2011
- Engelska.
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Ingår i: European Journal of Immunology. - Weinheim : Wiley-VCH Verlagsgesellschaft. - 0014-2980 .- 1521-4141. ; 41:4, s. 974-980
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The efficacy of many vaccines against intracellular bacteria depends on the generation of cell-mediated immunity, but studies to determine the duration of immunity are usually confounded by re-exposure. The causative agent of tularemia, Francisella tularensis, is rare in most areas and, therefore, tularemia vaccination is an interesting model for studies of the longevity of vaccine-induced cell-mediated immunity. Here, lymphocyte proliferation and cytokine production in response to F. tularensis were assayed in two groups of 16 individuals, vaccinated 1-3 or 27-34 years previously. As compared to naïve individuals, vaccinees of both groups showed higher proliferative responses and, out of 17 cytokines assayed, higher levels of MIP-1β, IFN-γ, IL-10, and IL-5 in response to recall stimulation. The responses were very similar in the two groups of vaccinees. A statistical model was developed to predict the immune status of the individuals and by use of two parameters, proliferative responses and levels of IFN-γ, 91.1% of the individuals were correctly classified. Using flow cytometry analysis, we demonstrated that during recall stimulation, expression of IFN-γ by CD4(+) CCR7(+) , CD4(+) CD62L(+) , CD8(+) CCR7(+) , and CD8(+) CD62L(+) cells significantly increased in samples from vaccinated donors. In conclusion, cell-mediated immunity was found to persist three decades after tularemia vaccination without evidence of decline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Cell-mediated immunity
- Francisella tularensis
- Persistence
- Vaccination
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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