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Dopamine release fr...
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Nevalainen, NinaUmeå universitet,Histologi med cellbiologi
(author)
Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-05-25
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Wiley,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-50743
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50743URI
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https://doi.org/10.1111/j.1471-4159.2011.07292.xDOI
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https://lup.lub.lu.se/record/1973277URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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L-DOPA is the most commonly used treatment for symptomatic control in patients with Parkinson's disease. Unfortunately, most patients develop severe side-effects, such as dyskinesia, upon chronic l-DOPA treatment. The patophysiology of dyskinesia is unclear; however, involvement of serotonergic nerve fibers in converting l-DOPA to dopamine has been suggested. Therefore, potassium-evoked dopamine release was studied after local application of l-DOPA in the striata of normal, dopamine- and dopamine/serotonin-lesioned l-DOPA naïve, and dopamine-denervated chronically l-DOPA-treated dyskinetic rats using in vivo chronoamperometry. The results revealed that local l-DOPA administration into normal and intact hemisphere of dopamine-lesioned l-DOPA naïve animals significantly increased the potassium-evoked dopamine release. l-DOPA application also increased the dopamine peak amplitude in the dopamine-depleted l-DOPA naïve striatum, although these dopamine levels were several-folds lower than in the normal striatum, whereas no increased dopamine release was found in the dopamine/serotonin-denervated striatum. In dyskinetic animals, local l-DOPA application did not affect the dopamine release, resulting in significantly attenuated dopamine levels compared with those measured in l-DOPA naïve dopamine-denervated striatum. To conclude, l-DOPA is most likely converted to dopamine in serotonergic nerve fibers in the dopamine-depleted striatum, but the dopamine release is several-fold lower than in normal striatum. Furthermore, l-DOPA loading does not increase the dopamine release in dyskinetic animals as found in l-DOPA naïve animals, despite similar density of serotonergic innervation. Thus, the dopamine overflow produced from the serotonergic nerve fibers appears not to be the major cause of dyskinetic behavior.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Af Bjerkén, SaraUmeå universitet,Histologi med cellbiologi(Swepub:umu)saaafn99
(author)
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Lundblad, MartinLund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups(Swepub:lu)mphy-mlu
(author)
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Gerhardt, Greg AAnatomy, Neurobiology, and Neurology, University of Kentucky Med Center, Lexington, KY, USA
(author)
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Strömberg, IngridUmeå universitet,Histologi med cellbiologi(Swepub:umu)inst0001
(author)
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Umeå universitetHistologi med cellbiologi
(creator_code:org_t)
Related titles
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In:Journal of Neurochemistry: Wiley118:1, s. 12-230022-30421471-4159
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