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Poor Folate Status ...
Poor Folate Status Predicts Persistent Diarrhea in 6-to 30-Month-Old North Indian Children
- Article/chapterEnglish2011
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Bethesda :American Society for Nutrition,2011
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LIBRIS-ID:oai:DiVA.org:umu-50862
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50862URI
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https://doi.org/10.3945/jn.111.144220DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Poor micronutrient status is associated with diarrheal illness, but it is not known whether low folate and/or cobalamin status are independent risk factors for diarrhea. We measured the association between plasma folate and cobalamin and subsequent diarrheal morbidity in a prospective cohort study of 2296 children aged 6-30 mo in New Delhi, India. Plasma concentrations of folate, cobalamin, total homocysteine (tHcy), and methylmalonic acid were determined at baseline. Whether a child had diarrhea was recorded during weekly visits in a 4-mo zinc supplementation trial. Diarrhea episodes lasting <7, >= 7, and >= 14 d were classified as acute, prolonged, and persistent, respectively. There was a total of 4596 child periods with acute, 633 with prolonged, and 117 with persistent diarrhea during follow-up. Children with plasma folate concentrations in the lowest quartile had higher odds of persistent diarrhea than children in the other quartiles [adjusted OR = 1.77(95% CI = 1.14, 2.75); P = 0.01]. This effect differed between boys [adjusted OR = 2.51 (95% CI = 1.47, 4.28)] and girls [adjusted OR = 1.03 (95% CI = 0.53, 2.01); P-interaction = 0.030]. We found a small but significant association between high plasma tHcy concentration and acute diarrhea [adjusted OR = 1.14 (95% CI = 1.04, 1.24); P = 0.006]. Plasma cobalamin concentration was not a predictor of diarrheal morbidity. In conclusion, poor folate status was an independent predictor of persistent diarrhea in this population. J. Nutr. 141: 2226-2232, 2011.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Taneja, Sunita
(author)
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Strand, Tor A.
(author)
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Ueland, Per M.
(author)
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Refsum, Helga
(author)
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Schneede, JörnUmeå universitet,Klinisk farmakologi(Swepub:umu)josc0012
(author)
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Nygard, Ottar
(author)
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Sommerfelt, Halvor
(author)
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Bhandari, Nita
(author)
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Umeå universitetKlinisk farmakologi
(creator_code:org_t)
Related titles
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In:Journal of NutritionBethesda : American Society for Nutrition141:12, s. 2226-22320022-31661541-6100
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