Search: onr:"swepub:oai:DiVA.org:umu-50885" >
Retention and mater...
Retention and maternal transfer of brominated dioxins in zebrafish (Danio rerio) and effects on reproduction, aryl hydrocarbon receptor-regulated genes, and ethoxyresorufin-O-deethylase (EROD) activity
-
- Norman Haldén, Anna (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Institutionen för biomedicin och veterinär folkhälsovetenskap, Sveriges Lantbruksuniversitet
-
- Arnoldsson, Kristina, 1961- (author)
- Umeå universitet,Kemiska institutionen,Environmental analytical chemistry using hyphenated and bioanalytical techniques
-
- Haglund, Peter, 1963- (author)
- Umeå universitet,Kemiska institutionen,Environmental analytical chemistry using hyphenated and bioanalytical techniques
-
show more...
-
- Mattsson, Anna (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Institutionen för biomedicin och veterinär folkhälsovetenskap; Sveriges Lantbruksuniversitet
-
- Ullerås, Erik (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Institutionen för biomedicin och veterinär folkhälsovetenskap, Sveriges Lantbruksuniversitet
-
- Sturve, Joachim, 1966 (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
-
- Norrgren, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Institutionen för biomedicin och veterinär folkhälsovetenskap, Sveriges Lantbruksuniversitet
-
show less...
-
(creator_code:org_t)
-
- Oxford : Elsevier, 2011
- 2011
- English.
-
In: Aquatic Toxicology. - Oxford : Elsevier. - 0166-445X .- 1879-1514. ; 102:3-4, s. 150-161
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Brominated dioxins have recently been detected in Baltic Sea biota. Due to their similarities to the highly toxic chlorinated dioxins, concern has been raised about their potential biological effects. The present study investigated retention and effects of brominated dioxins in adult zebrafish, as well as maternal transfer and effects on offspring. We exposed adult zebrafish for nine weeks via feed to 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) or to a mixture of brominated dioxins (Baltic Sea mixture), which was designed to reflect relative concentrations found in Baltic Sea biota. We studied spawning success, gonad morphology, hepatic vitellogenin gene expression, and offspring early life-stage development to investigate effects on zebrafish reproduction. Hepatic ethoxyresorufin-O-deethylase (EROD) activity and hepatic expression of a number of aryl hydrocarbon receptor (AHR)-regulated genes were studied to investigate if the brominated dioxins can activate gene transcription through the AHR pathway in zebrafish. In addition, glutathione reductase activity and expression of genes involved in adaptive responses to intracellular stress were studied to investigate potential stress effects of brominated dioxins. After nine weeks of exposure, all brominated dioxins spiked to the feed were detected in female fish and transferred to eggs. Exposure to the Baltic Sea mixture and TBDD clearly induced AHR-regulated genes and EROD activity. Exposure to TBDD reduced spawning success, altered ovarian morphology and reduced hepatic vitellogenin gene expression, which implies that TBDD has a similar effect pattern as the chlorinated analogue. Overall, our results show that dietary exposure to sublethal concentrations of brominated dioxins may impair reproductive physiology in fish and induce AHR-regulated genes. (C) 2011 Elsevier B.V. All rights reserved.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Annan veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Other Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap -- Miljö- och naturvårdsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences -- Environmental Sciences related to Agriculture and Land-use (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Keyword
- zebrafish
- polybrominated dibenzo-p-dioxins
- dietary exposure
- maternal transfer
- CYP1A1 induction
- reproduction
- ekotoxikologi
- Ecotoxicology
- zebrafish
- polybrominated dibenzo-p-dioxins
- dietary exposure
- maternal transfer
- cyp1a1 induction
- reproduction
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database