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Factors associated with inflammation markers, a cross-sectional analysis

Clendenen, Tess V (author)
Koenig, Karen L (author)
Arslan, Alan A (author)
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Lukanova, Annekatrin (author)
Berrino, Franco (author)
Gu, Yian (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Idahl, Annika (author)
Umeå universitet,Obstetrik och gynekologi
Krogh, Vittorio (author)
Lokshin, Anna E (author)
Lundin, Eva (author)
Umeå universitet,Patologi
Muti, Paola (author)
Marrangoni, Adele (author)
Nolen, Brian M (author)
Ohlson, Nina (author)
Umeå universitet,Patologi
Shore, Roy E (author)
Sieri, Sabina (author)
Zeleniuch-Jacquotte, Anne (author)
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 (creator_code:org_t)
Elsevier BV, 2011
2011
English.
In: Cytokine. - : Elsevier BV. - 1043-4666 .- 1096-0023. ; 56:3, s. 769-778
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFα, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1β, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

C-reactive protein; Cross-sectional studies; Cytokines; Cytokine receptors; Epidemiologic factors

Publication and Content Type

ref (subject category)
art (subject category)

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