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Factors associated ...
Factors associated with inflammation markers, a cross-sectional analysis
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Clendenen, Tess V (author)
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Koenig, Karen L (author)
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Arslan, Alan A (author)
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Lukanova, Annekatrin (author)
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Berrino, Franco (author)
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Gu, Yian (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi
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Krogh, Vittorio (author)
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Lokshin, Anna E (author)
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Muti, Paola (author)
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Marrangoni, Adele (author)
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Nolen, Brian M (author)
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- Ohlson, Nina (author)
- Umeå universitet,Patologi
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Shore, Roy E (author)
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Sieri, Sabina (author)
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Zeleniuch-Jacquotte, Anne (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Cytokine. - : Elsevier BV. - 1043-4666 .- 1096-0023. ; 56:3, s. 769-778
- Related links:
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https://air.unimi.it...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFα, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1β, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- C-reactive protein; Cross-sectional studies; Cytokines; Cytokine receptors; Epidemiologic factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cytokine
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- By the author/editor
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Clendenen, Tess ...
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Koenig, Karen L
-
Arslan, Alan A
-
Lukanova, Anneka ...
-
Berrino, Franco
-
Gu, Yian
-
show more...
-
Hallmans, Göran
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Idahl, Annika
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Krogh, Vittorio
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Lokshin, Anna E
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Lundin, Eva
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Muti, Paola
-
Marrangoni, Adel ...
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Nolen, Brian M
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Ohlson, Nina
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Shore, Roy E
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Sieri, Sabina
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Zeleniuch-Jacquo ...
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show less...
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and Medical Biotechn ...
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MEDICAL AND HEAL ...
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and Cell and Molecul ...
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MEDICAL AND HEAL ...
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Cytokine
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Umeå University