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Signal regulatory p...
Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.
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- Sato-Hashimoto, Miho (author)
- Gunma University
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- Saito, Yasuyuki (author)
- Gunma University
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- Ohnishi, Hiroshi (author)
- Gunma University
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- Iwamura, Hiroko (author)
- Gunma University
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- Kanazawa, Yoshitake (author)
- Gunma University
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- Kaneko, Tetsuya (author)
- Gunma University
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- Kusakari, Shinya (author)
- Gunma University
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- Kotani, Takenori (author)
- Gunma University
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- Mori, Munemasa (author)
- Gunma University
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- Murata, Yoji (author)
- Kobe University Graduate School of Medicine
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- Okazawa, Hideki (author)
- Kobe University Graduate School of Medicine
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- Ware, Carl F (author)
- Sanford-Burnham Medical Research Institute, La Jolla
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- Oldenborg, Per-Arne (author)
- Umeå universitet,Histologi med cellbiologi
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Nojima, Yoshihisa (author)
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- Matozaki, Takashi (author)
- Kobe University Graduate School of Medicine
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(creator_code:org_t)
- 2011-07-01
- 2011
- English.
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In: Journal of Immunology. - : American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 187:1, s. 291-297
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
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- The molecular basis for formation of lymphoid follicle and its homeostasis in the secondary lymphoid organs remains unclear. Signal regulatory protein α (SIRPα), an Ig superfamily protein that is predominantly expressed in dendritic cells or macrophages, mediates cell-cell signaling by interacting with CD47, another Ig superfamily protein. In this study, we show that the size of the T cell zone as well as the number of CD4(+) T cells were markedly reduced in the spleen of mice bearing a mutant (MT) SIRPα that lacks the cytoplasmic region compared with those of wild-type mice. In addition, the expression of CCL19 and CCL21, as well as of IL-7, which are thought to be important for development or homeostasis of the T cell zone, was markedly decreased in the spleen of SIRPα MT mice. By the use of bone marrow chimera, we found that hematopoietic SIRPα is important for development of the T cell zone as well as the expression of CCL19 and CCL21 in the spleen. The expression of lymphotoxin and its receptor, lymphotoxin β receptor, as well as the in vivo response to lymphotoxin β receptor stimulation were also decreased in the spleen of SIRPα MT mice. CD47-deficient mice also manifested phenotypes similar to SIRPα MT mice. These data suggest that SIRPα as well as its ligand CD47 are thus essential for steady-state homeostasis of T cells in the spleen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Sato-Hashimoto, ...
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Saito, Yasuyuki
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Ohnishi, Hiroshi
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Iwamura, Hiroko
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Kanazawa, Yoshit ...
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Kaneko, Tetsuya
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show more...
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Kusakari, Shinya
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Kotani, Takenori
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Mori, Munemasa
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Murata, Yoji
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Okazawa, Hideki
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Ware, Carl F
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Oldenborg, Per-A ...
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Nojima, Yoshihis ...
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Matozaki, Takash ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Journal of Immun ...
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Umeå University