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The diflunisal trial :
The diflunisal trial : study accrual and drug tolerance
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Berk, John L (author)
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- Suhr, Ole B (author)
- Umeå universitet,Medicin
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Sekijima, Yoshiki (author)
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Yamashita, Taro (author)
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Heneghan, Michael (author)
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Zeldenrust, Steven R (author)
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Ando, Yukio (author)
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Ikeda, Shu-ichi (author)
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Gorevic, Peter (author)
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Merlini, Giampaolo (author)
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Kelly, Jeffrey W (author)
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Skinner, Martha (author)
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Bisbee, Alice B (author)
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Dyck, Peter J (author)
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Obici, Laura (author)
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(creator_code:org_t)
- 2012-05-02
- 2012
- English.
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In: Amyloid. - : Informa UK Limited. - 1350-6129 .- 1744-2818. ; 19:S1, s. 37-38
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Familial amyloidotic polyneuropathy (FAP) is a protein folding disorder that induces neuropathy and cardiomyopathy, leading to death within 7-15 years after onset of clinical disease. In vitro, small ligands binding the thyroid hormone docking site stabilize tetrameric transthyretin, inhibiting amyloid fibril formation. We undertook a randomized, placebo-controlled clinical trial to determine whether diflunisal, a well-known non-steroidal anti-inflammatory drug (NSAID) alters neurologic disease progression in FAP. We enrolled 130 subjects with wide age and FAP mutation representation. To date, few recognized complications of NSAIDs have occurred in the study cohort. Data collection will be completed by November 2012.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- Clinical trials
- diflunisal
- FAP
- neuropathy
- transthyretin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Amyloid
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- By the author/editor
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Berk, John L
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Suhr, Ole B
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Sekijima, Yoshik ...
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Yamashita, Taro
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Heneghan, Michae ...
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Zeldenrust, Stev ...
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show more...
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Ando, Yukio
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Ikeda, Shu-ichi
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Gorevic, Peter
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Merlini, Giampao ...
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Kelly, Jeffrey W
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Skinner, Martha
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Bisbee, Alice B
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Dyck, Peter J
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Obici, Laura
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Amyloid
- By the university
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Umeå University