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Lowering apolipopro...
Lowering apolipoprotein CIII delays onset of type 1 diabetes
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Holmberg, Rebecka (author)
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- Refai, Essam (author)
- Karolinska Institutet
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- Höög, Anders (author)
- Karolinska Institutet
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Crooke, Rosanne M (author)
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Graham, Mark (author)
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- Olivecrona, Gunilla (author)
- Umeå universitet,Fysiologisk kemi
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- Berggren, Per-Olof (author)
- Karolinska Institutet
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- Juntti-Berggren, Lisa (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2011-06-13
- 2011
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 108:26, s. 10685-10689
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.
Publication and Content Type
- ref (subject category)
- art (subject category)
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