An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity

Nordström, Ulrika, 1971- (author): Umeå universitet,Umeå centrum för molekylär medicin (UCMM)

Maier, Esther, 1974- (author): Umeå universitet,Umeå centrum för molekylär medicin (UCMM)

Jessell, Thomas M (author)

Edlund, Thomas (author): Umeå universitet,Umeå centrum för molekylär medicin (UCMM)

(creator_code:org_t)

2006-07-18
2006
English.
In: PLoS biology. - : Public library of science. - 1544-9173 .- 1545-7885. ; 4:8, s. 1438-1452

Related links:: http://www.ncbi.nlm....; show more...; https://umu.diva-por... (primary) (Raw object); https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmental organization of the vertebrate central nervous system. In the hindbrain and spinal cord, distinctions in the rostrocaudal identity of progenitor cells are associated with the generation of different motor neuron subtypes. Two fundamental classes of motor neurons, those with dorsal (dMN) and ventral (vMN) exit points, are generated over largely non-overlapping rostrocaudal domains of the caudal neural tube. Cdx and Hox genes are important determinants of the rostrocaudal identity of neural progenitor cells, but the link between early patterning signals, neural Cdx and Hox gene expression, and the generation of dMN and vMN subtypes, is unclear. Using an in vitro assay of neural differentiation, we provide evidence that an early Wnt-based program is required to interact with a later retinoic acid- and fibroblast growth factor–mediated mechanism to generate a pattern of Cdx and Hox profiles characteristic of hindbrain and spinal cord progenitor cells that prefigure the generation of vMNs and dMNs.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

By the author/editor: Nordström, Ulrik ...; Maier, Esther, 1 ...; Jessell, Thomas ...; Edlund, Thomas

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.