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Coordinated regulation of tissue type plasminogen activator and plasminogen activator inhibitor type-1 gene expression in hypophysectomized rat ovaries during GnRHa-induced ovulation.

Liu, Y X (author)
Liu, K (author)
Peng, X R (author)
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Ny, Tor (author)
Umeå universitet,Institutionen för medicinsk kemi och biofysik
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 (creator_code:org_t)
1994
1994
English.
In: Science in China. Series B, Chemistry, life sciences & earth sciences. - 1001-652X. ; 37:7, s. 820-30
  • Journal article (peer-reviewed)
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  • In this study we have demonstrated that both granulosa and theca-interstitial cells of hypophysectomized rat ovaries are capable of synthesizing tPA and PAI-1. Injection of a GnRH agonist can markedly induce these gene expressions in the ovary in a cell-specific and time-coordinated manner, so that a surge of tPA mRNA and its activity in both granulosa and theca-interstitial cells was obtained just prior to ovulation. Theca-interstitial cells make PAI-1 become the most active in the ovary. Both the amount PAI-1 mRNA and its activity in the cells reach the maximum level 6 h before the tPA peak. By contrast, granulosa cells produce only a little amount of PAI-1 (most increase tPA activity), and both PAI-1 mRNA and activity in the cells reach the maximum after ovulation. The coordinated regulation of tPA and PAI-1 in the ovary may fine-tune the peak of tPA activity which may be important for the regulation of the ovulatory process. The changes of tPA and PAI-1 in the ovarian cells of hypophysectomized rats during GnRHa-induced ovulation are similar to that in intact rats during hCG-induced ovulation, suggesting that the ovulatory process can be modulated by different regulatory signals mediated by influencing the coordinated expression of both tPA and PAI-1.

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Liu, Y X
Liu, K
Peng, X R
Ny, Tor
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