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  • Ros, Martine M. (author)

Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier BV,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-61170
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61170URI
  • https://doi.org/10.3945/ajcn.111.032920DOI
  • https://lup.lub.lu.se/record/3189700URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125290600URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bueno-de-Mesquita, H. Bas (author)
  • Kampman, Ellen (author)
  • Aben, Katja K. H. (author)
  • Buechner, Frederike L. (author)
  • Jansen, Eugene H. J. M. (author)
  • van Gils, Carla H. (author)
  • Egevad, LarsKarolinska Institutet (author)
  • Overvad, Kim (author)
  • Tjonneland, Anne (author)
  • Roswall, Nina (author)
  • Boutron-Ruault, Marie Christine (author)
  • Kvaskoff, Marina (author)
  • Perquier, Florence (author)
  • Kaaks, Rudolf (author)
  • Chang-Claude, Jenny (author)
  • Weikert, Steffen (author)
  • Boeing, Heiner (author)
  • Trichopoulou, Antonia (author)
  • Lagiou, Pagona (author)
  • Dilis, Vardis (author)
  • Palli, Domenico (author)
  • Pala, Valeria (author)
  • Sacerdote, Carlotta (author)
  • Tumino, Rosario (author)
  • Panico, Salvatore (author)
  • Peeters, Petra H. M. (author)
  • Gram, Inger T. (author)
  • Skeie, Guri (author)
  • Huerta, Jose Maria (author)
  • Barricarte, Aurelio (author)
  • Quiros, Jose Ramon (author)
  • Sanchez, Maria Jose (author)
  • Buckland, Genevieve (author)
  • Larranaga, Nerea (author)
  • Ehrnström, RoyLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-reh (author)
  • Wallström, PeterLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)pe6853wa (author)
  • Ljungberg, BörjeUmeå universitet,Urologi och andrologi,Njurcancer(Swepub:umu)bolj0001 (author)
  • Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
  • Key, Timothy J. (author)
  • Allen, Naomi E. (author)
  • Khaw, Kay-Tee (author)
  • Wareham, Nick (author)
  • Brennan, Paul (author)
  • Riboli, Elio (author)
  • Kiemeney, Lambertus A. (author)
  • Karolinska InstitutetPatologi, Malmö (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: Elsevier BV96:4, s. 902-9100002-91651938-3207

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