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  • van Mierlo, Joël T (author)

Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-08-16
  • Public Library of Science (PLoS),2012
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-61306
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61306URI
  • https://doi.org/10.1371/journal.ppat.1002872DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi. We detected viral small RNAs with a signature of Dicer-2 dependent small interfering RNAs in Nora virus infected Drosophila. Furthermore, we demonstrate that the Nora virus VP1 protein contains RNAi suppressive activity in vitro and in vivo that enhances pathogenicity of recombinant Sindbis virus in an RNAi dependent manner. Nora virus VP1 and the viral suppressor of RNAi of Cricket paralysis virus (1A) antagonized Argonaute-2 (AGO2) Slicer activity of RNA induced silencing complexes pre-loaded with a methylated single-stranded guide strand. The convergent evolution of AGO2 suppression in two unrelated insect RNA viruses highlights the importance of AGO2 in antiviral defense.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bronkhorst, Alfred W (author)
  • Overheul, Gijs J (author)
  • Sadanandan, Sajna AUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Hultmark(Swepub:umu)saan0083 (author)
  • Ekström, Jens-OlaUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Hultmark(Swepub:umu)jeek0010 (author)
  • Heestermans, Marco (author)
  • Hultmark, DanUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institute of Biomedical Technology, University of Tampere, Tampere, Finland,Hultmark, Univ Tampere, Inst Biomed Technol, FIN-33101 Tampere, Finland(Swepub:umu)dahu0001 (author)
  • Antoniewski, Christophe (author)
  • van Rij, Ronald P (author)
  • Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten) (creator_code:org_t)

Related titles

  • In:PLoS Pathogens: Public Library of Science (PLoS)8:81553-73661553-7374

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