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Invasin of Yersinia...
Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
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Lundgren, E (author)
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- Carballeira, N (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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Vazquez, R (author)
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Dubinina, E (author)
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Bränden, H (author)
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Persson, H (author)
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Wolf-Watz, H (author)
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(creator_code:org_t)
- 1996
- 1996
- English.
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In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 64:3, s. 829-35
- Related links:
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https://urn.kb.se/re...
Abstract
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- The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
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- art (subject category)
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