Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

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Galluzzi, Lorenzo (author)

Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

Article/chapterEnglish2012

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Cambridge :Cell press,2012
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LIBRIS-ID:oai:DiVA.org:umu-61575
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61575URI
https://doi.org/10.1016/j.celrep.2012.06.017DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.

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NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng

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Vitale, Ilio (author)
Senovilla, Laura (author)
Olaussen, Ken Andre (author)
Pinna, Guillaume (author)
Eisenberg, Tobias (author)
Goubar, Aicha (author)
Martins, Isabelle (author)
Michels, Judith (author)
Kratassiouk, Gueorgui (author)
Carmona-Gutierrez, Didac (author)
Scoazec, Marie (author)
Vacchelli, Erika (author)
Schlemmer, Frederic (author)
Kepp, Oliver (author)
Shen, Shensi (author)
Tailler, Maximilien (author)
Niso-Santano, Mireia (author)
Morselli, Eugenia (author)
Criollo, Alfredo (author)
Adjemian, Sandy (author)
Jemaa, Mohamed (author)
Chaba, Kariman (author)
Pailleret, Claire (author)
Michaud, Mickael (author)
Pietrocola, Federico (author)
Tajeddine, Nicolas (author)
Rouge, Thibault de La Motte (author)
Araujo, Natalia (author)
Morozova, Nadya (author)
Robert, Thomas (author)
Ripoche, Hugues (author)
Commo, Frederic (author)
Besse, Benjamin (author)
Validire, Pierre (author)
Fouret, Pierre (author)
Robin, Angelique (author)
Dorvault, Nicolas (author)
Girard, Philippe (author)
Gouy, Sebastien (author)
Pautier, Patricia (author)
Jaegemann, Nora (author)
Nickel, Ann-Christin (author)
Marsili, Sabrina (author)
Paccard, Caroline (author)
Servant, Nicolas (author)
Hupe, Philippe (author)
Behrens, Carmen (author)
Behnam-Motlagh, ParvizUmeå universitet,Klinisk kemi(Swepub:umu)pabe0001 (author)
Kohno, Kimitoshi (author)
Cremer, Isabelle (author)
Damotte, Diane (author)
Alifano, Marco (author)
Midttun, Oivind (author)
Ueland, Per Magne (author)
Lazar, Vladimir (author)
Dessen, Philippe (author)
Zischka, Hans (author)
Chatelut, Etienne (author)
Castedo, Maria (author)
Madeo, Frank (author)
Barillot, Emmanuel (author)
Thomale, Juergen (author)
Wistuba, Ignacio Ivan (author)
Sautes-Fridman, Catherine (author)
Zitvogel, Laurence (author)
Soria, Jean-Charles (author)
Harel-Bellan, Annick (author)
Kroemer, Guido (author)
Umeå universitetKlinisk kemi (creator_code:org_t)

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In:Cell ReportsCambridge : Cell press2:2, s. 257-2692211-1247

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By the author/editor: Galluzzi, Lorenz ...; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken An ...; Pinna, Guillaume; Eisenberg, Tobia ...; show more...; Goubar, Aicha; Martins, Isabell ...; Michels, Judith; Kratassiouk, Gue ...; Carmona-Gutierre ...; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frede ...; Kepp, Oliver; Shen, Shensi; Tailler, Maximil ...; Niso-Santano, Mi ...; Morselli, Eugeni ...; Criollo, Alfredo; Adjemian, Sandy; Jemaa, Mohamed; Chaba, Kariman; Pailleret, Clair ...; Michaud, Mickael; Pietrocola, Fede ...; Tajeddine, Nicol ...; Rouge, Thibault ...; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angelique; Dorvault, Nicola ...; Girard, Philippe; Gouy, Sebastien; Pautier, Patrici ...; Jaegemann, Nora; Nickel, Ann-Chri ...; Marsili, Sabrina; Paccard, Carolin ...; Servant, Nicolas; Hupe, Philippe; Behrens, Carmen; Behnam-Motlagh, ...; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Oivind; Ueland, Per Magn ...; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienn ...; Castedo, Maria; Madeo, Frank; Barillot, Emmanu ...; Thomale, Juergen; Wistuba, Ignacio ...; Sautes-Fridman, ...; Zitvogel, Lauren ...; Soria, Jean-Char ...; Harel-Bellan, An ...; Kroemer, Guido; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

Articles in the publication: Cell Reports

By the university: Umeå University

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