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Leptin and soluble ...
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Aleksandrova, Krasimira
(author)
Leptin and soluble leptin receptor in risk of colorectal cancer in the European prospective investigation into Cancer and nutrition cohort
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Philadelphia, USA :American Association for Cancer Research,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-61772
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61772URI
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https://doi.org/10.1158/0008-5472.CAN-12-0465DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P-trend = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P-trend = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P-trend = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P-trend = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328-37. (C) 2012 AACR.
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Boeing, Heiner
(author)
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Jenab, Mazda
(author)
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Bueno-de-Mesquita, H. Bas
(author)
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Jansen, Eugene
(author)
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van Duijnhoven, Franzel J. B.
(author)
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Rinaldi, Sabina
(author)
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Fedirko, Veronika
(author)
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Romieu, Isabelle
(author)
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Riboli, Elio
(author)
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Gunter, Marc J.
(author)
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Westphal, Sabine
(author)
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Overvad, Kim
(author)
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Tjonneland, Anne
(author)
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Halkjaer, Jytte
(author)
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Racine, Antoine
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Clavel-Chapelon, Francoise
(author)
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Kaaks, Rudolf
(author)
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Lukanova, Annekatrin
(author)
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Trichopoulou, Antonia
(author)
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Lagiou, Pagona
(author)
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Trichopoulos, Dimitrios
(author)
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Mattiello, Amalia
(author)
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Pala, Valeria
(author)
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Palli, Domenico
(author)
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Tumino, Rosario
(author)
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Vineis, Paolo
(author)
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Buckland, Genevieve
(author)
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Sanchez, Maria-Jose
(author)
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Amiano, Pilar
(author)
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Maria Huerta, Jose
(author)
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Barricarte, Aurelio
(author)
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Menendez, Virginia
(author)
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Peeters, Petra H.
(author)
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Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001
(author)
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Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001
(author)
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Allen, Naomi E.
(author)
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Crowe, Francesca L.
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nickolas
(author)
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Pischon, Tobias
(author)
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Umeå universitetKardiologi
(creator_code:org_t)
Related titles
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In:Cancer ResearchPhiladelphia, USA : American Association for Cancer Research72:20, s. 5328-53370008-54721538-7445
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Aleksandrova, Kr ...
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Boeing, Heiner
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Jenab, Mazda
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Bueno-de-Mesquit ...
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Jansen, Eugene
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van Duijnhoven, ...
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Rinaldi, Sabina
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Fedirko, Veronik ...
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Romieu, Isabelle
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Riboli, Elio
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Gunter, Marc J.
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Westphal, Sabine
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Overvad, Kim
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Tjonneland, Anne
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Halkjaer, Jytte
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Racine, Antoine
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Kaaks, Rudolf
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Lukanova, Anneka ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Mattiello, Amali ...
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Pala, Valeria
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Palli, Domenico
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Tumino, Rosario
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Vineis, Paolo
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Buckland, Genevi ...
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Sanchez, Maria-J ...
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Amiano, Pilar
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Maria Huerta, Jo ...
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Barricarte, Aure ...
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Menendez, Virgin ...
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Peeters, Petra H ...
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Söderberg, Stefa ...
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Palmqvist, Richa ...
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Allen, Naomi E.
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Crowe, Francesca ...
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Khaw, Kay-Tee
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Wareham, Nickola ...
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Pischon, Tobias
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancer Research
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Umeå University