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Phospho-Akt Immunor...
Phospho-Akt Immunoreactivity in Prostate Cancer : Relationship to Disease Severity and Outcome, Ki67 and Phosphorylated EGFR Expression
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- Hammarsten, Peter (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Cipriano, Mariateresa (författare)
- Umeå universitet,Farmakologi
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- Josefsson, Andreas (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Stattin, Pär (författare)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Egevad, Lars (författare)
- Karolinska Institutet
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Granfors, Torvald (författare)
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- Fowler, Christopher J. (författare)
- Umeå universitet,Farmakologi
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(creator_code:org_t)
- 2012-10-25
- 2012
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:10, s. e47994-
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: In the present study, we have investigated the prognostic usefulness of phosphorylated Akt immunoreactivity (pAkt-IR) in prostate cancer using a well-characterised tissue microarray from men who had undergone transurethral resection due to lower urinary tract symptoms. Methodology/Principal Findings: pAkt-IR in prostate epithelial and tumour cells was assessed using a monoclonal anti-pAkt (Ser(473)) antibody. Immunoreactive intensity was determined for 282 (tumour) and 240 (non-mlignant tissue) cases. Tumour pAkt-IR scores correlated with Gleason score, tumour Ki67-IR (a marker of cell proliferation) and tumour phosphorylated epidermal growth factor receptor (pEGFR)-IR. For cases followed with expectancy, a high tumour pAkt-IR was associated with a poor disease-specific survival, and the prognostic information provided by this biomarker was additive to that provided by either (but not both) tumour pEFGR-IR or Ki67-IR. Upon division of the cases with respect to their Gleason scores, the prognostic value of pAkt-IR was seen for patients with Gleason score 8-10, but not for patients with Gleason score 6-7. Conclusions/Significance: Tumour pAkt-IR is associated with both disease severity and disease-specific survival. However, its clinical use as a biomarker is limited, since it does not provide prognostic information in patients with Gleason scores 6-7.
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