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Summary of the evid...
Summary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet
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Ancelle-Park, R. (author)
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Armaroli, P. (author)
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Ascunce, N. (author)
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Bisanti, L. (author)
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Bellisario, C. (author)
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Broeders, M. (author)
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Cogo, C. (author)
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de Koning, H. (author)
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Duffy, S. W. (author)
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Frigerio, A. (author)
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Giordano, L. (author)
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Hofvind, S. (author)
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- Jonsson, Håkan (author)
- Umeå universitet,Onkologi
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Lynge, E. (author)
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Massat, N. (author)
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Miccinesi, G. (author)
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Moss, S. (author)
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Naldoni, C. (author)
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Njor, S. (author)
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- Nyström, Lennarth (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Paap, E. (author)
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Paci, E. (author)
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Patnick, J. (author)
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Ponti, A. (author)
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Puliti, D. (author)
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Segnan, N. (author)
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Von Karsa, L. (author)
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- Tornberg, S. (author)
- Karolinska Institutet
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Zappa, M. (author)
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Zorzi, M. (author)
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(creator_code:org_t)
- 2012-09-12
- 2012
- English.
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In: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 19, s. 5-13
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives To construct a European 'balance sheet' of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women. Methods From the studies reviewed, the primary benefit of screening, breast cancer mortality reduction, was compared with the main harms, over-diagnosis and false-positive screening results (FPRs). Results Pooled estimates of breast cancer mortality reduction among invited women were 25% in incidence-based mortality studies and 31% in case-control studies (38% and 48% among women actually screened). Estimates of over-diagnosis ranged from 1% to 10% of the expected incidence in the absence of screening. The combined estimate of over-diagnosis for screened women, from European studies correctly adjusted for lead time and underlying trend, was 6.5%. For women undergoing 10 biennial screening tests, the estimated cumulative risk of a FPR followed by non-invasive assessment was 17%, and 3% having an invasive assessment. For every 1000 women screened biennially from age 50-51 until age 68-69 and followed up to age 79, an estimated seven to nine lives are saved, four cases are over-diagnosed, 170 women have at least one recall followed by non-invasive assessment with a negative result and 30 women have at least one recall followed by invasive procedures yielding a negative result. Conclusions The chance of saving a woman's life by population-based mammographic screening of appropriate quality is greater than that of over-diagnosis. Service screening in Europe achieves a mortality benefit at least as great as the randomized controlled trials. These outcomes should be communicated to women offered service screening in Europe.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ancelle-Park, R.
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Armaroli, P.
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Ascunce, N.
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Bisanti, L.
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Bellisario, C.
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Broeders, M.
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show more...
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Cogo, C.
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de Koning, H.
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Duffy, S. W.
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Frigerio, A.
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Giordano, L.
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Hofvind, S.
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Jonsson, Håkan
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Lynge, E.
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Massat, N.
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Miccinesi, G.
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Moss, S.
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Naldoni, C.
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Njor, S.
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Nyström, Lennart ...
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Paap, E.
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Paci, E.
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Patnick, J.
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Ponti, A.
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Puliti, D.
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Segnan, N.
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Von Karsa, L.
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Tornberg, S.
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Zappa, M.
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Zorzi, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Journal of Medic ...
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Umeå University
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Karolinska Institutet