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Women with acute intermittent porphyria have a defect in 5 alpha-steroid production during the menstrual cycle
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- Innala, Eva (author)
- Umeå universitet,Obstetrik och gynekologi,Dept of Clinical Science, Obstetrics and Gynecology, Umea University
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- Bäckström, Torbjörn (author)
- Umeå universitet,Obstetrik och gynekologi,Dept of Clinical Science, Obstetrics and Gynecology, Umea University
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa,Department of Women's and Children's Health, Uppsala University, Uppsala
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- (creator_code:org_t)
- 2012-11-01
- 2012
- English.
- In: Acta Obstetricia et Gynecologica Scandinavica. - : John Wiley & Sons. - 0001-6349 .- 1600-0412. ; 91:12, s. 1445-1452
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Objective. To measure serum concentrations of progesterone, estradiol and 5 alpha- and 5 beta-reduced progesterone metabolites in the follicular and luteal phases of the menstrual cycle in women with latent acute intermittent porphyria and manifest acute intermittent porphyria in comparison with healthy control women. Design. A descriptive study with repeated measurements during a complete, ovulatory menstrual cycle. Setting. University hospital out-patient clinic. Population. Thirty-two women with DNA-diagnosed acute intermittent porphyria and 20 healthy control women. Methods. Blood samples for serum progesterone, estradiol, allopregnanolone and pregnanolone were drawn on predefined menstrual cycle days, twice in the follicular phase and three times in the luteal phase. Serum levels of estradiol and progesterone were analysed with commercial kits. Allopregnanolone and pregnanolone levels were analysed with radioimmunoassay following diethylether extraction and celite column chromatography. Main outcome measures. Changes in serum levels of progesterone, estradiol, allopregnanolone and pregnanolone throughout the menstrual cycle. Results. Women with acute intermittent porphyria displayed lower serum concentrations of allopregnanolone in comparison with healthy control women, the difference being most prominent in the luteal phase (p < 0.001). Levels of pregnanolone did not differ significantly between groups. No significant difference was found between women with latent acute intermittent porphyria and manifest acute intermittent porphyria. Conclusions. Decreased levels of the 5 alpha-reduced progesterone metabolite allopregnanolone were found in the menstrual cycle of women with acute intermittent porphyria. This has not been reported previously and could indicate a reduced 5 alpha-reductase type 1 capacity in the ovary and liver among these women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Acute intermittent porphyria
- menstrual cycle
- progesterone
- allopregnanolone
- pregnanolone
Publication and Content Type
- ref (subject category)
- art (subject category)
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