Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants.

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Karpe, FKarolinska Institutet (author)

Chylomicron/chylomicron remnant turnover in humans : evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants.

Article/chapterEnglish1997

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1997
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LIBRIS-ID:oai:DiVA.org:umu-65039
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-65039URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1929138URI

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Language:English
Summary in:English

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The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may be deposited in the arterial wall and by this become potentially atherogenic. This study deals with the in vivo transformation of larger-sized chylomicrons and chylomicron remnants to smaller-sized remnants. Twelve healthy men aged 22 to 45 years were given a fatty meal to which retinyl palmitate (RP) had been added. Plasmapheresis was performed 4 1/2 h after meal intake to isolate approximately 400 ml plasma. The RP-rich plasma was re-injected to the subject 24 h later. The RP content was determined in whole plasma and in Svedberg flotation rate fractions (Sf) > 400, Sf 60-400 and Sf 20-60. A compartmental model was developed for the kinetic analysis. Lipoprotein fractions showed minimal signs of aggregation, thus arguing for well-preserved postprandial lipoproteins. Approximately a fourth [23% (4-68%)] of the RP-containing lipoproteins in the Sf > 400 pool was converted to smaller species (Sf 60-400). Conversion of material from the Sf 60-400 to the Sf 20-60 fraction could not be detected. In a second study a large bolus dose of a triglyceride emulsion (Intralipid) was injected to subjects shortly after the RP-labeled plasma to investigate the endothelial binding of the chylomicron/chylomicron remnants. RP material in the Sf > 400 fraction rapidly returned to plasma, arguing for margination of chylomicrons, whereas the corresponding effect was minimal in the Sf 60-400 and Sf 20-60 fractions. The formation of small chylomicron remnants from the larger chylomicron/chylomicron remnant species is limited and large chylomicron/chylomicron remnants are not evenly distributed in plasma, rather they show signs of being marginated to the vascular endothelium.

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Olivecrona, TUmeå universitet,Fysiologisk kemi(Swepub:umu)thol0003 (author)
Hamsten, AKarolinska Institutet (author)
Hultin, MUmeå universitet,Fysiologisk kemi(Swepub:umu)mahu0016 (author)
Karolinska InstitutetFysiologisk kemi (creator_code:org_t)

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In:Journal of Lipid Research38:5, s. 949-610022-22751539-7262

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By the author/editor: Karpe, F; Olivecrona, T; Hamsten, A; Hultin, M

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine

Articles in the publication: Journal of Lipid ...

By the university: Umeå University; Karolinska Institutet

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