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Effects of fucosyla...
Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen
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Xu, Hong-Tao (author)
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Zhao, Yao-Feng (author)
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Lian, Zheng-Xing (author)
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Fan, Bao-Liang (author)
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Zhao, Zhi-Hui (author)
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Yu, Shu-Yang (author)
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Dai, Yun-Ping (author)
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Wang, Li-Li (author)
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Niu, Hui-Ling (author)
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Li, Ning (author)
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- Hammarström, Lennart (author)
- Karolinska Institutet,Umeå universitet,Institutionen för odontologi
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- Borén, Thomas (author)
- Umeå universitet,Oral mikrobiologi,Institutionen för odontologi
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- Sjöström, Rolf (author)
- Umeå universitet,Institutionen för odontologi
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(creator_code:org_t)
- Beijing : WJG Press, 2004
- 2004
- English.
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In: World Journal of Gastroenterology. - Beijing : WJG Press. - 1007-9327 .- 2219-2840. ; 10:14, s. 2063-2066
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http://www.ncbi.nlm....
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Aim:To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori (H pylon) binding to Lewis b antigen. Methods:A mammary gland expression vector containing human α1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human(α1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using Hpylori. Results: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of Hpylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit Hpylori binding to Lewis b antigen. Conclusion: The use of “humanized“ animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for Hpylori infection.
Keyword
- Animals
- Bacterial Adhesion
- Blood Group Antigens/*metabolism
- Female
- Food; Genetically Modified
- Fucosyltransferases/*genetics/metabolism
- Gene Expression
- Goats
- Helicobacter pylori/*metabolism/physiology
- Humans
- Lewis Blood-Group System/*immunology
- Mammary Glands; Animal/enzymology
- Mice
- Mice; Transgenic
- Milk/enzymology/*physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Xu, Hong-Tao
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Zhao, Yao-Feng
-
Lian, Zheng-Xing
-
Fan, Bao-Liang
-
Zhao, Zhi-Hui
-
Yu, Shu-Yang
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show more...
-
Dai, Yun-Ping
-
Wang, Li-Li
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Niu, Hui-Ling
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Li, Ning
-
Hammarström, Len ...
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Borén, Thomas
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Sjöström, Rolf
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show less...
- Articles in the publication
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World Journal of ...
- By the university
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Umeå University
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Karolinska Institutet