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- Xu, Hong-Tao (author)
Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Beijing :WJG Press,2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-6652
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6652URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123472470URI
- https://doi.org/10.3748/wjg.v10.i14.2063DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Aim:To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori (H pylon) binding to Lewis b antigen. Methods:A mammary gland expression vector containing human α1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human(α1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using Hpylori. Results: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of Hpylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit Hpylori binding to Lewis b antigen. Conclusion: The use of “humanized“ animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for Hpylori infection.
Subject headings and genre
- Animals
- Bacterial Adhesion
- Blood Group Antigens/*metabolism
- Female
- Food; Genetically Modified
- Fucosyltransferases/*genetics/metabolism
- Gene Expression
- Goats
- Helicobacter pylori/*metabolism/physiology
- Humans
- Lewis Blood-Group System/*immunology
- Mammary Glands; Animal/enzymology
- Mice
- Mice; Transgenic
- Milk/enzymology/*physiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhao, Yao-Feng (author)
- Lian, Zheng-Xing (author)
- Fan, Bao-Liang (author)
- Zhao, Zhi-Hui (author)
- Yu, Shu-Yang (author)
- Dai, Yun-Ping (author)
- Wang, Li-Li (author)
- Niu, Hui-Ling (author)
- Li, Ning (author)
- Hammarström, LennartKarolinska Institutet,Umeå universitet,Institutionen för odontologi (author)
- Borén, ThomasUmeå universitet,Oral mikrobiologi,Institutionen för odontologi(Swepub:umu)thbo0001 (author)
- Sjöström, RolfUmeå universitet,Institutionen för odontologi(Swepub:umu)rosj0001 (author)
- Umeå universitetInstitutionen för odontologi (creator_code:org_t)
Related titles
- In:World Journal of GastroenterologyBeijing : WJG Press10:14, s. 2063-20661007-93272219-2840
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15237435&dopt=Citation
- https://doi.org/10.3748/wjg.v10.i14.2063
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6652
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123472470
- https://doi.org/10.3748/wjg.v10.i14.2063
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