Search: onr:"swepub:oai:DiVA.org:umu-67055" > Ischemic stroke is ...
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000 | 05551naa a2200997 4500 | |
001 | oai:DiVA.org:umu-67055 | |
003 | SwePub | |
008 | 130312s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-670552 URI |
024 | 7 | a https://doi.org/10.1002/ana.238382 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Williams, Frances M. K.4 aut |
245 | 1 0 | a Ischemic stroke is associated with the ABO locus :b the EuroCLOT study |
264 | c 2013-02-04 | |
264 | 1 | b Wiley-Blackwell,c 2013 |
338 | a print2 rdacarrier | |
500 | a Errata Annals of Neurology, 2014: 75 (1), 166-167. doi:10.1002/ana.24105 | |
520 | a Objective: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods: Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3). Results: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (p < 5 x 10(-8)) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 x 10(-186)), rs10665 with FVII (p = 2.4 x 10(-47)), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 x 10(-57)) and factor VIII (p = 1.2 x 10(-36)). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811). Interpretation: ABO gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Carter, Angela M.4 aut |
700 | 1 | a Hysi, Pirro G.4 aut |
700 | 1 | a Surdulescu, Gabriela4 aut |
700 | 1 | a Hodgkiss, Dylan4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Traylor, Matthew4 aut |
700 | 1 | a Bevan, Steve4 aut |
700 | 1 | a Dichgans, Martin4 aut |
700 | 1 | a Rothwell, Peter M. W.4 aut |
700 | 1 | a Sudlow, Cathie4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Silander, Kaisa4 aut |
700 | 1 | a Kaunisto, Mari4 aut |
700 | 1 | a Wagner, Peter4 aut |
700 | 1 | a Saarela, Olli4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Arveiler, Dominique4 aut |
700 | 1 | a Ferrieres, Jean4 aut |
700 | 1 | a Wiklund, Per-Gunnaru Umeå universitet,Medicin4 aut0 (Swepub:umu)pewi0010 |
700 | 1 | a Ikram, M. Arfan4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Boncoraglio, Giorgio B.4 aut |
700 | 1 | a Parati, Eugenio A.4 aut |
700 | 1 | a Helgadottir, Anna4 aut |
700 | 1 | a Gretarsdottir, Solveig4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Seshadri, Sudha4 aut |
700 | 1 | a DeStefano, Anita4 aut |
700 | 1 | a Gschwendtner, Andreas4 aut |
700 | 1 | a Psaty, Bruce4 aut |
700 | 1 | a Longstreth, Will4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Cheng, Yu-Ching4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Ferrario, Marco4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Levi, Christopher4 aut |
700 | 1 | a Attia, John4 aut |
700 | 1 | a Holliday, Elizabeth G.4 aut |
700 | 1 | a Scott, Rodney J.4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Sharma, Pankaj4 aut |
700 | 1 | a Furie, Karen L.4 aut |
700 | 1 | a Rosand, Jonathan4 aut |
700 | 1 | a Nalls, Mike4 aut |
700 | 1 | a Meschia, James4 aut |
700 | 1 | a Mosely, Thomas H.4 aut |
700 | 1 | a Evans, Alun4 aut |
700 | 1 | a Palotie, Aarno4 aut |
700 | 1 | a Markus, Hugh S.4 aut |
700 | 1 | a Grant, Peter J.4 aut |
700 | 1 | a Spector, Tim D.4 aut |
710 | 2 | a Umeå universitetb Medicin4 org |
773 | 0 | t Annals of Neurologyd : Wiley-Blackwellg 73:1, s. 16-31q 73:1<16-31x 0364-5134x 1531-8249 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.23838 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67055 |
856 | 4 8 | u https://doi.org/10.1002/ana.23838 |
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