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Genetic variation i...
Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-10-17
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Wiley,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-67376
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67376URI
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https://doi.org/10.1002/ijc.27836DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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High dairy protein intake has been found to be associated with increased prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). To further examine this possible relationship, we investigated the hypothesis that a genetic polymorphism in the lactase (LCT) gene might be associated with elevated dairy product intake and increased prostate cancer risk in a casecontrol study nested in EPIC. The C/T-13910 lactase variant (rs4988235) was genotyped in 630 men with prostate cancer and 873 matched control participants. Dairy product consumption was assessed by diet questionnaire. Odds ratios (ORs) for prostate cancer in relation to lactase genotype were estimated by conditional logistic regression. Lactase genotype frequency varied significantly between countries, with frequencies of the T (lactase persistence) allele ranging from 7% in Greece to 79% in Denmark. Intake of milk and total dairy products varied significantly by lactase genotype after adjustment for recruitment center; adjusted mean intakes of milk were 44.4, 69.8 and 82.3 g/day among men with CC, CT and TT genotypes, respectively. The lactase variant was not significantly associated with prostate cancer risk, both in our data (adjusted OR for TT vs. CC homozygotes: 1.10, 95% CI: 0.761.59) and in a meta-analysis of all the published data (combined OR for T allele carriers vs. CC homozygotes: 1.12, 0.961.32). These findings show that while variation in the lactase gene is associated with milk intake in men, the lactase polymorphism does not have a large effect on prostate cancer risk.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Appleby, Paul N.
(author)
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Siddiq, Afshan
(author)
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Allen, Naomi E.
(author)
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Kaaks, Rudolf
(author)
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Canzian, Federico
(author)
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Feller, Silke
(author)
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Tjønneland, Anne
(author)
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Føns Johnsen, Nina
(author)
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Overvad, Kim
(author)
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Ramon Quiros, J.
(author)
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Gonzalez, Carlos A.
(author)
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Sanchez, Maria-Jose
(author)
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Larranaga, Nerea
(author)
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Chirlaque, Maria-Dolores
(author)
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Barricarte, Aurelio
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nick
(author)
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Trichopoulou, Antonia
(author)
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Valanou, Elisavet
(author)
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Oustoglou, Erifili
(author)
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Palli, Domenico
(author)
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Sieri, Sabina
(author)
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Tumino, Rosario
(author)
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Sacerdote, Carlotta
(author)
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Bueno-de-Mesquita, H. B(as).
(author)
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Stattin, PärUmeå universitet,Urologi och andrologi,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)past0003
(author)
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Ferrari, Pietro
(author)
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Johansson, MattiasUmeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France(Swepub:umu)masmas97
(author)
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Norat, Teresa
(author)
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Riboli, Elio
(author)
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Key, Timothy J.
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
Related titles
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In:International Journal of Cancer: Wiley132:8, s. 1901-19100020-71361097-0215
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Travis, Ruth C.
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Appleby, Paul N.
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Siddiq, Afshan
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Allen, Naomi E.
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Kaaks, Rudolf
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Canzian, Federic ...
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show more...
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Feller, Silke
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Tjønneland, Anne
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Føns Johnsen, Ni ...
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Overvad, Kim
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Ramon Quiros, J.
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Gonzalez, Carlos ...
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Sanchez, Maria-J ...
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Larranaga, Nerea
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Khaw, Kay-Tee
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Wareham, Nick
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Trichopoulou, An ...
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Valanou, Elisave ...
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Oustoglou, Erifi ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Stattin, Pär
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Ferrari, Pietro
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Johansson, Matti ...
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Norat, Teresa
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Riboli, Elio
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Key, Timothy J.
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Umeå University