Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

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Leenders, Max (author)

Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

Article/chapterEnglish2013

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2013-01-19
Springer Science and Business Media LLC,2013
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LIBRIS-ID:oai:DiVA.org:umu-67380
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67380URI
https://doi.org/10.1007/s10552-012-0138-0DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed. Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (< 0.02) were followed up in 2,323 cases and 2,340 controls from eight case-control studies (PanC4) that participated in PanScan2. The correlation of SNPs with metabolite levels was assessed for 649 controls from the European Prospective Investigation into Cancer and Nutrition. When both stages were combined, we observed suggestive associations with PanCa for rs10887710 (MAT1A) (OR 1.13, 95 %CI 1.04-1.23), rs1552462 (SYT9) (OR 1.27, 95 %CI 1.02-1.59), and rs7074891 (CUBN) (OR 1.91, 95 %CI 1.12-3.26). After correcting for multiple comparisons, no significant associations were observed in either the first or second stage. The three suggested SNPs showed no correlations with one-carbon biomarkers. This is the largest genetic study to date to examine the relation between germline variations in OCM-related genes polymorphisms and the risk of PanCa. Suggestive evidence for an association between polymorphisms and PanCa was observed among the cohort-nested studies, but this did not replicate in the case-control studies. Our results do not strongly support the hypothesis that genes related to OCM play a role in pancreatic carcinogenesis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Pancreatic cancer
One-carbon metabolism
Polymorphisms
Biomarkers
Epidemiology

Added entries (persons, corporate bodies, meetings, titles ...)

Bhattacharjee, Samsiddhi (author)
Vineis, Paolo (author)
Stevens, Victoria (author)
Bueno-de-Mesquita, H. Bas (author)
Shu, Xiao-Ou (author)
Amundadottir, Laufey (author)
Gross, Myron (author)
Tobias, Geoffrey S. (author)
Wactawski-Wende, Jean (author)
Arslan, Alan A. (author)
Duell, Eric J. (author)
Fuchs, Charles S. (author)
Gallinger, Steven (author)
Hartge, Patricia (author)
Hoover, Robert N. (author)
Holly, Elizabeth A. (author)
Jacobs, Eric J. (author)
Klein, Alison P. (author)
Kooperberg, Charles (author)
LaCroix, Andrea (author)
Li, Donghui (author)
Mandelson, Margaret T. (author)
Olson, Sara H. (author)
Petersen, Gloria (author)
Risch, Harvey A. (author)
Yu, Kai (author)
Wolpin, Brian M. (author)
Zheng, Wei (author)
Agalliu, Ilir (author)
Albanes, Demetrius (author)
Boutron-Ruault, Marie-Christine (author)
Bracci, Paige M. (author)
Buring, Julie E. (author)
Canzian, Federico (author)
Chang, Kenneth (author)
Chanock, Stephen J. (author)
Cotterchio, Michelle (author)
Gaziano, J. Michael (author)
Giovanucci, Edward L. (author)
Goggins, Michael (author)
Hallmans, GöranUmeå universitet,Näringsforskning,Enheten för biobanksforskning(Swepub:umu)goha0001 (author)
Hankinson, Susan E. (author)
Hoffman-Bolton, Judith A. (author)
Hunter, David J. (author)
Hutchinson, Amy (author)
Jacobs, Kevin B. (author)
Jenab, Mazda (author)
Khaw, Kay-Tee (author)
Kraft, Peter (author)
Krogh, Vittorio (author)
Kurtz, Robert C. (author)
McWilliams, Robert R. (author)
Mendelsohn, Julie B. (author)
Patel, Alpa V. (author)
Rabe, Kari G. (author)
Riboli, Elio (author)
Tjonneland, Anne (author)
Trichopoulos, Dimitrios (author)
Virtamo, Jarmo (author)
Visvanathan, Kala (author)
Elena, Joanne W. (author)
Yu, Herbert (author)
Zeleniuch-Jacquotte, Anne (author)
Stolzenberg-Solomon, Rachael Z. (author)
Umeå universitetNäringsforskning (creator_code:org_t)

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In:Cancer Causes and Control: Springer Science and Business Media LLC24:3, s. 595-6020957-52431573-7225

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By the author/editor: Leenders, Max; Bhattacharjee, S ...; Vineis, Paolo; Stevens, Victori ...; Bueno-de-Mesquit ...; Shu, Xiao-Ou; show more...; Amundadottir, La ...; Gross, Myron; Tobias, Geoffrey ...; Wactawski-Wende, ...; Arslan, Alan A.; Duell, Eric J.; Fuchs, Charles S ...; Gallinger, Steve ...; Hartge, Patricia; Hoover, Robert N ...; Holly, Elizabeth ...; Jacobs, Eric J.; Klein, Alison P.; Kooperberg, Char ...; LaCroix, Andrea; Li, Donghui; Mandelson, Marga ...; Olson, Sara H.; Petersen, Gloria; Risch, Harvey A.; Yu, Kai; Wolpin, Brian M.; Zheng, Wei; Agalliu, Ilir; Albanes, Demetri ...; Boutron-Ruault, ...; Bracci, Paige M.; Buring, Julie E.; Canzian, Federic ...; Chang, Kenneth; Chanock, Stephen ...; Cotterchio, Mich ...; Gaziano, J. Mich ...; Giovanucci, Edwa ...; Goggins, Michael; Hallmans, Göran; Hankinson, Susan ...; Hoffman-Bolton, ...; Hunter, David J.; Hutchinson, Amy; Jacobs, Kevin B.; Jenab, Mazda; Khaw, Kay-Tee; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C.; McWilliams, Robe ...; Mendelsohn, Juli ...; Patel, Alpa V.; Rabe, Kari G.; Riboli, Elio; Tjonneland, Anne; Trichopoulos, Di ...; Virtamo, Jarmo; Visvanathan, Kal ...; Elena, Joanne W.; Yu, Herbert; Zeleniuch-Jacquo ...; Stolzenberg-Solo ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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