Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

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Fältnamn	Indikatorer	Metadata
000		07739naa a2201129 4500
001		oai:DiVA.org:umu-67583
003		SwePub
008		130325s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:60557ad5-7923-447d-b86a-8b851fb62f88
009		oai:DiVA.org:uu-197380
009		oai:prod.swepub.kib.ki.se:126230314
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-675832 URI
024	7	a https://doi.org/10.3945/jn.112.1720492 DOI
024	7	a https://lup.lub.lu.se/record/36715352 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1973802 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1262303142 URI
040		a (SwePub)umud (SwePub)lud (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hruby, Adela4 aut
245	1 0	a Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
264	1	b Elsevier BV,c 2013
338		a print2 rdacarrier
520		a Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700	1	a Ngwa, Julius S.4 aut
700	1	a Renström, Fridau Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm
700	1	a Wojczynski, Mary K.4 aut
700	1	a Ganna, Andreau Karolinska Institutet4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001
700	1	a Houston, Denise K.4 aut
700	1	a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)pafr0003
700	1	a Kanoni, Stavroula4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Lemaitre, Rozenn N.4 aut
700	1	a Manichaikul, Ani4 aut
700	1	a North, Kari E.4 aut
700	1	a Ntalla, Ioanna4 aut
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
700	1	a Tanaka, Toshiko4 aut
700	1	a van Rooij, Frank J. A.4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Djousse, Luc4 aut
700	1	a Grigoriou, Efi.4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Tandläkarutbildning4 aut0 (Swepub:umu)injo0003
700	1	a Lohman, Kurt K.4 aut
700	1	a Pankow, James S.4 aut
700	1	a Raitakari, Olli T.4 aut
700	1	a Riserus, Ulfu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
700	1	a Yannakoulia, Mary4 aut
700	1	a Zillikens, M. Carola4 aut
700	1	a Hassanali, Neelam4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Mozaffarian, Dariush4 aut
700	1	a Papoutsakis, Constantina4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Groves, Christopher J.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a McCarthy, Mark I.4 aut
700	1	a Mikkila, Vera4 aut
700	1	a Mukamal, Kenneth4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Borecki, Ingrid B.4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a Dedoussis, George V.4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Ingelsson, Erik4 aut
700	1	a Kahonen, Mika4 aut
700	1	a Kao, W. H. Linda4 aut
700	1	a Kritchevsky, Stephen B.4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Prokopenko, Inga4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Franks, Paul W.u Umeå universitet,Medicin4 aut0 (Swepub:umu)pafr0003
700	1	a Meigs, James B.4 aut
700	1	a McKeown, Nicola M.4 aut
700	1	a Nettleton, Jennifer A.4 aut
710	2	a Umeå universitetb Medicin4 org
773	0	t Journal of Nutritiond : Elsevier BVg 143:3, s. 345-353q 143:3<345-353x 0022-3166x 1541-6100
856	4	u https://academic.oup.com/jn/article-pdf/143/3/345/23977044/345.pdf
856	4	u http://dx.doi.org/10.3945/jn.112.172049y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67583
856	4 8	u https://doi.org/10.3945/jn.112.172049
856	4 8	u https://lup.lub.lu.se/record/3671535
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197380
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:126230314

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By the author/editor: Hruby, Adela; Ngwa, Julius S.; Renström, Frida; Wojczynski, Mary ...; Ganna, Andrea; Hallmans, Göran; show more...; Houston, Denise ...; Franks, Paul; Kanoni, Stavroul ...; Lehtimaki, Terho; Lemaitre, Rozenn ...; Manichaikul, Ani; North, Kari E.; Ntalla, Ioanna; Sonestedt, Emily; Tanaka, Toshiko; van Rooij, Frank ...; Bandinelli, Stef ...; Djousse, Luc; Grigoriou, Efi.; Johansson, Ingeg ...; Lohman, Kurt K.; Pankow, James S.; Raitakari, Olli ...; Riserus, Ulf; Yannakoulia, Mar ...; Zillikens, M. Ca ...; Hassanali, Neela ...; Liu, Yongmei; Mozaffarian, Dar ...; Papoutsakis, Con ...; Syvänen, Ann-Chr ...; Uitterlinden, An ...; Viikari, Jorma; Groves, Christop ...; Hofman, Albert; Lind, Lars; McCarthy, Mark I ...; Mikkila, Vera; Mukamal, Kenneth; Franco, Oscar H.; Borecki, Ingrid ...; Cupples, L. Adri ...; Dedoussis, Georg ...; Ferrucci, Luigi; Hu, Frank B.; Ingelsson, Erik; Kahonen, Mika; Kao, W. H. Linda; Kritchevsky, Ste ...; Orho-Melander, M ...; Prokopenko, Inga; Rotter, Jerome I ...; Siscovick, David ...; Witteman, Jacque ...; Franks, Paul W.; Meigs, James B.; McKeown, Nicola ...; Nettleton, Jenni ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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