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Myosin heavy chain composition of the human lateral pterygoid and digastric muscles in young adults and elderly.

Monemi, M (author)
Umeå universitet,Institutionen för odontologi
Liu, Jingxia (author)
Umeå universitet,Anatomi
Thornell, Lars-Eric (author)
Umeå universitet,Anatomi
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Eriksson, Per-Olof (author)
Umeå universitet,Institutionen för odontologi
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 (creator_code:org_t)
2000
2000
English.
In: Journal of Muscle Research and Cell Motility. - 0142-4319 .- 1573-2657. ; 21:4, s. 303-312
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The myosin heavy chain (MyHC) content in different parts of, two jaw opening muscle, the human lateral pterygoid and the digastric muscles of five young adult and five elderly subjects (mean age 22 and 73 years, respectively) was determined, using gel electrophoresis and immunohistochemical methods. The lateral pterygoid of both young and elderly contained predominantly slow MyHC, and fast A MyHC was the major fast isoform. In contrast, the digastric was composed of slow, fast A and fast X MyHCs in about equal proportions in both age groups. About half of the lateral pterygoid fibres contained mixtures of slow and fast MyHCs, often together with alpha-cardiac MyHC. In the digastric, co-existence of slow and fast MyHCs was rare, and alpha-cardiac MyHC was lacking. On the other hand, co-expression of fast A and fast X MyHCs was found more often in the digastric than in the lateral pterygoid. In both age groups about half of the digastric IIB fibres contained solely fast X MyHC. In the lateral pterygoid, type IIB fibres with pure fast X MyHC was found in only one subject. The lateral pterygoid in elderly showed a significant amount of fibres with solely fast A MyHC, which were occasionally found in young adults. In the digastric, no significant differences were found between young and elderly, although the muscles of elderly contained lower mean value of slow MyHC, as compared to that of young muscles. It is concluded that the lateral pterygoid and the digastric muscles differ not only in the MyHC composition but also in modifications of the MyHC phenotypes during aging, suggesting that they have separate roles in jaw opening function.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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Monemi, M
Liu, Jingxia
Thornell, Lars-E ...
Eriksson, Per-Ol ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Cell and Molecul ...
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Journal of Muscl ...
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Umeå University

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