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Cisplatin Resistanc...
Cisplatin Resistance Associated with PARP Hyperactivation
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Michels, Judith (author)
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Vitale, Ilio (author)
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Galluzzi, Lorenzo (author)
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Adam, Julien (author)
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Olaussen, Ken Andre (author)
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Kepp, Oliver (author)
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Senovilla, Laura (author)
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Talhaoui, Ibtissam (author)
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Guegan, Justine (author)
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Enot, David Pierre (author)
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Talbot, Monique (author)
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Robin, Angelique (author)
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Girard, Philippe (author)
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Orear, Cedric (author)
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Lissa, Delphine (author)
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Sukkurwala, Abdul Qader (author)
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Garcia, Pauline (author)
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- Behnam Motlagh, Parviz (author)
- Umeå universitet,Klinisk kemi
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Kohno, Kimitoshi (author)
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Wu, Gen Sheng (author)
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Brenner, Catherine (author)
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Dessen, Philippe (author)
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Saparbaev, Murat (author)
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Soria, Jean-Charles (author)
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Castedo, Maria (author)
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Kroemer, Guido (author)
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(creator_code:org_t)
- Philadelphia : American Association for Cancer Research, 2013
- 2013
- English.
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In: Cancer Research. - Philadelphia : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 73:7, s. 2271-2280
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Non-small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin. Cells manifesting elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) responded to pharmacologic PARP inhibitors as well as to PARP1-targeting siRNAs by initiating a DNA damage response that translated into cell death following the activation of the intrinsic pathway of apoptosis. Moreover, PARP1-overexpressing tumor cells and xenografts displayed elevated levels of PAR, which predicted the response to PARP inhibitors in vitro and in vivo more accurately than PARP1 expression itself. Thus, a majority of CDDP-resistant cancer cells appear to develop a dependency to PARP1, becoming susceptible to PARP inhibitor-induced apoptosis. Cancer Res; 73(7); 2271-80.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Michels, Judith
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Vitale, Ilio
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Galluzzi, Lorenz ...
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Adam, Julien
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Olaussen, Ken An ...
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Kepp, Oliver
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show more...
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Senovilla, Laura
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Talhaoui, Ibtiss ...
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Guegan, Justine
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Enot, David Pier ...
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Talbot, Monique
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Robin, Angelique
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Girard, Philippe
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Orear, Cedric
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Lissa, Delphine
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Sukkurwala, Abdu ...
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Garcia, Pauline
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Behnam Motlagh, ...
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Kohno, Kimitoshi
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Wu, Gen Sheng
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Brenner, Catheri ...
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Dessen, Philippe
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Saparbaev, Murat
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Soria, Jean-Char ...
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Castedo, Maria
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Kroemer, Guido
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Research
- By the university
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Umeå University