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  • Hendrickson, Sara J. (author)

Plasma Carotenoid- and Retinol-Weighted Multi-SNP Scores and Risk of Breast Cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Philadelphia, PA, USA :American Association for Cancer Research,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-73582
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-73582URI
  • https://doi.org/10.1158/1055-9965.EPI-13-0017DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Dietary and circulating carotenoids have been inversely associated with breast cancer risk, but observed associations may be due to confounding. Single-nucleotide polymorphisms (SNPs) in beta-carotene 15,15'-monooxygenase 1 (BCMO1), a gene encoding the enzyme involved in the first step of synthesizing vitamin A from dietary carotenoids, have been associated with circulating carotenoid concentrations and may serve as unconfounded surrogates for those biomarkers. We determined associations between variants in BCMO1 and breast cancer risk in a large cohort consortium. Methods: We used unconditional logistic regression to test four SNPs in BCMO1 for associations with breast cancer risk in 9,226 cases and 10,420 controls from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). We also tested weighted multi-SNP scores composed of the two SNPs with strong, confirmed associations with circulating carotenoid concentrations. Results: Neither the individual SNPs nor the weighted multi-SNP scores were associated with breast cancer risk [OR (95% confidence interval) comparing extreme quintiles of weighted multi-SNP scores = 1.04 (0.94-1.16) for beta-carotene, 1.08 (0.98-1.20) for alpha-carotene, 1.04 (0.94-1.16) for beta-cryptoxanthin, 0.95 (0.87-1.05) for lutein/zeaxanthin, and 0.92 (0.83-1.02) for retinol]. Furthermore, no associations were observed when stratifying by estrogen receptor status, but power was limited. Conclusions: Our results do not support an association between SNPs associated with circulating carotenoid concentrations and breast cancer risk. Impact: Future studies will need additional genetic surrogates and/or sample sizes at least three times larger to contribute evidence of a causal link between carotenoids and breast cancer. (C) 2013 AACR.

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  • Lindström, Sara (author)
  • Eliassen, A. Heather (author)
  • Rosner, Bernard A. (author)
  • Chen, Constance (author)
  • Barrdahl, Myrto (author)
  • Brinton, Louise (author)
  • Buring, Julie (author)
  • Canzian, Federico (author)
  • Chanock, Stephen (author)
  • Clavel-Chapelon, Francoise (author)
  • Figueroa, Jonine D. (author)
  • Gapstur, Susan M. (author)
  • Garcia-Closas, Montserrat (author)
  • Gaudet, Mia M. (author)
  • Haiman, Christopher A. (author)
  • Hazra, Aditi (author)
  • Henderson, Brian (author)
  • Hoover, Robert (author)
  • Husing, Anika (author)
  • Johansson, MattiasUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Int Agcy Res Canc, F-69372 Lyon, France (author)
  • Kaaks, Rudolf (author)
  • Khaw, Kay-Tee (author)
  • Kolonel, Laurence N. (author)
  • Le Marchand, Loic (author)
  • Lissowska, Jolanta (author)
  • Lund, Eiliv (author)
  • McCullough, Marjorie L. (author)
  • Peplonska, Beata (author)
  • Riboli, Elio (author)
  • Sacerdote, Carlotta (author)
  • Sanchez, Maria-Jose (author)
  • Tjonneland, Anne (author)
  • Trichopoulos, Dimitrios (author)
  • van Gils, Carla H. (author)
  • Yeager, Meredith (author)
  • Kraft, Peter (author)
  • Hunter, David J. (author)
  • Ziegler, Regina G. (author)
  • Willett, Walter C. (author)
  • Umeå universitetInstitutionen för folkhälsa och klinisk medicin (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology, Biomarkers and PreventionPhiladelphia, PA, USA : American Association for Cancer Research22:5, s. 927-9361055-99651538-7755

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