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Dietary flavonoid, ...
Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study
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Zamora-Ros, Raul (author)
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Fedirko, Veronika (author)
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Trichopoulou, Antonia (author)
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González, Carlos A (author)
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Bamia, Christina (author)
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Trepo, Elisabeth (author)
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Nöthlings, Ute (author)
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Duarte-Salles, Talita (author)
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Serafini, Mauro (author)
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Bredsdorff, Lea (author)
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Overvad, Kim (author)
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Tjønneland, Anne (author)
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Halkjaer, Jytte (author)
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Fagherazzi, Guy (author)
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Perquier, Florence (author)
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Boutron-Ruault, Marie-Christine (author)
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Katzke, Verena (author)
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Lukanova, Annekatrin (author)
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Floegel, Anna (author)
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Boeing, Heiner (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Saieva, Calogero (author)
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Agnoli, Claudia (author)
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Mattiello, Amalia (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Bas Bueno-de-Mesquita, H (author)
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Peeters, Petra H M (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Engeset, Dagrun (author)
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Skeie, Guri (author)
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Vicente Argüelles, Marcial (author)
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Molina-Montes, Esther (author)
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Dorronsoro, Miren (author)
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José Tormo, María (author)
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- Ardanaz, Eva (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
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- Landberg, Rikard (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science
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Khaw, Kay-Tee (author)
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Wareham, Nicholas J (author)
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Crowe, Francesca L (author)
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Riboli, Elio (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
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- 2013-06-04
- 2013
- English.
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In: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 133:10, s. 2429-2443
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://res.slu.se/i...
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http://kipublication...
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Abstract
Subject headings
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- Limited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 477,206 subjects (29.8% male) recruited from ten Western European countries, was analyzed. Flavonoid, lignan and NEAC intakes were calculated using a compilation of existing food composition databases linked to dietary information from validated dietary questionnaires. Dietary NEAC was based on ferric reducing antioxidant capacity (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases (66.5% men) were identified. Using Cox regression, multivariable adjusted models showed a borderline nonsignificant association of HCC with total flavonoid intake (highest versus lowest tertile, HR = 0.65, 95% CI: 0.40-1.04; ptrend = 0.065), but not with lignans. Among flavonoid subclasses, flavanols were inversely associated with HCC risk (HR = 0.62, 95% CI: 0.39-0.99; ptrend = 0.06). Dietary NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; ptrend = 0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; ptrend = 0.002), but statistical significance was lost after exclusion of the first 2 years of follow-up. This study suggests that higher intake of dietary flavanols and antioxidants may be associated with a reduced HCC risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- flavonoids
- lignans
- dietary intake
- antioxidant capacity
- hepatocellular carcinoma
- EPIC
- flavonoids
- lignans
- dietary intake
- antioxidant capacity
- hepatocellular carcinoma
- EPIC
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zamora-Ros, Raul
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Fedirko, Veronik ...
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Trichopoulou, An ...
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González, Carlos ...
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Bamia, Christina
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Trepo, Elisabeth
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show more...
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Nöthlings, Ute
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Duarte-Salles, T ...
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Serafini, Mauro
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Bredsdorff, Lea
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Overvad, Kim
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Tjønneland, Anne
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Halkjaer, Jytte
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Fagherazzi, Guy
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Perquier, Floren ...
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Boutron-Ruault, ...
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Katzke, Verena
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Lukanova, Anneka ...
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Floegel, Anna
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Boeing, Heiner
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Lagiou, Pagona
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Trichopoulos, Di ...
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Saieva, Calogero
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Agnoli, Claudia
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Mattiello, Amali ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bas Bueno-de-Mes ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Engeset, Dagrun
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Skeie, Guri
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Vicente Argüelle ...
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Molina-Montes, E ...
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Dorronsoro, Mire ...
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José Tormo, Marí ...
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Ardanaz, Eva
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Ericson, Ulrika
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Sonestedt, Emily
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Sund, Malin, 197 ...
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Landberg, Rikard
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Crowe, Francesca ...
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Riboli, Elio
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Jenab, Mazda
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University
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Swedish University of Agricultural Sciences
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Karolinska Institutet