Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

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Zamora-Ros, Raul (author)

Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

Article/chapterEnglish2013

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2013-06-04
Wiley-Blackwell,2013
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LIBRIS-ID:oai:DiVA.org:umu-76720
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76720URI
https://doi.org/10.1002/ijc.28257DOI
https://lup.lub.lu.se/record/4106235URI
https://res.slu.se/id/publ/55555URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127344654URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Limited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 477,206 subjects (29.8% male) recruited from ten Western European countries, was analyzed. Flavonoid, lignan and NEAC intakes were calculated using a compilation of existing food composition databases linked to dietary information from validated dietary questionnaires. Dietary NEAC was based on ferric reducing antioxidant capacity (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases (66.5% men) were identified. Using Cox regression, multivariable adjusted models showed a borderline nonsignificant association of HCC with total flavonoid intake (highest versus lowest tertile, HR = 0.65, 95% CI: 0.40-1.04; ptrend = 0.065), but not with lignans. Among flavonoid subclasses, flavanols were inversely associated with HCC risk (HR = 0.62, 95% CI: 0.39-0.99; ptrend = 0.06). Dietary NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; ptrend = 0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; ptrend = 0.002), but statistical significance was lost after exclusion of the first 2 years of follow-up. This study suggests that higher intake of dietary flavanols and antioxidants may be associated with a reduced HCC risk.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
flavonoids
lignans
dietary intake
antioxidant capacity
hepatocellular carcinoma
EPIC
flavonoids
lignans
dietary intake
antioxidant capacity
hepatocellular carcinoma
EPIC

Added entries (persons, corporate bodies, meetings, titles ...)

Fedirko, Veronika (author)
Trichopoulou, Antonia (author)
González, Carlos A (author)
Bamia, Christina (author)
Trepo, Elisabeth (author)
Nöthlings, Ute (author)
Duarte-Salles, Talita (author)
Serafini, Mauro (author)
Bredsdorff, Lea (author)
Overvad, Kim (author)
Tjønneland, Anne (author)
Halkjaer, Jytte (author)
Fagherazzi, Guy (author)
Perquier, Florence (author)
Boutron-Ruault, Marie-Christine (author)
Katzke, Verena (author)
Lukanova, Annekatrin (author)
Floegel, Anna (author)
Boeing, Heiner (author)
Lagiou, Pagona (author)
Trichopoulos, Dimitrios (author)
Saieva, Calogero (author)
Agnoli, Claudia (author)
Mattiello, Amalia (author)
Tumino, Rosario (author)
Sacerdote, Carlotta (author)
Bas Bueno-de-Mesquita, H (author)
Peeters, Petra H M (author)
Weiderpass, ElisabeteKarolinska Institutet (author)
Engeset, Dagrun (author)
Skeie, Guri (author)
Vicente Argüelles, Marcial (author)
Molina-Montes, Esther (author)
Dorronsoro, Miren (author)
José Tormo, María (author)
Ardanaz, EvaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)extLU-05 (author)
Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe (author)
Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-eso (author)
Sund, Malin,1972-Umeå universitet,Kirurgi(Swepub:umu)masu0021 (author)
Landberg, RikardSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science(Swepub:slu)51036 (author)
Khaw, Kay-Tee (author)
Wareham, Nicholas J (author)
Crowe, Francesca L (author)
Riboli, Elio (author)
Jenab, Mazda (author)
Karolinska InstitutetInstitutionen för kliniska vetenskaper, Malmö (creator_code:org_t)
Sveriges lantbruksuniversitet

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In:International Journal of Cancer: Wiley-Blackwell133:10, s. 2429-24430020-71361097-0215

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By the author/editor: Zamora-Ros, Raul; Fedirko, Veronik ...; Trichopoulou, An ...; González, Carlos ...; Bamia, Christina; Trepo, Elisabeth; show more...; Nöthlings, Ute; Duarte-Salles, T ...; Serafini, Mauro; Bredsdorff, Lea; Overvad, Kim; Tjønneland, Anne; Halkjaer, Jytte; Fagherazzi, Guy; Perquier, Floren ...; Boutron-Ruault, ...; Katzke, Verena; Lukanova, Anneka ...; Floegel, Anna; Boeing, Heiner; Lagiou, Pagona; Trichopoulos, Di ...; Saieva, Calogero; Agnoli, Claudia; Mattiello, Amali ...; Tumino, Rosario; Sacerdote, Carlo ...; Bas Bueno-de-Mes ...; Peeters, Petra H ...; Weiderpass, Elis ...; Engeset, Dagrun; Skeie, Guri; Vicente Argüelle ...; Molina-Montes, E ...; Dorronsoro, Mire ...; José Tormo, Marí ...; Ardanaz, Eva; Ericson, Ulrika; Sonestedt, Emily; Sund, Malin, 197 ...; Landberg, Rikard; Khaw, Kay-Tee; Wareham, Nichola ...; Crowe, Francesca ...; Riboli, Elio; Jenab, Mazda; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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