Gene x physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry

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Fältnamn	Indikatorer	Metadata
000		06633naa a2201033 4500
001		oai:DiVA.org:umu-79909
003		SwePub
008		130904s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:127174699
009		oai:DiVA.org:uu-206656
009		oai:DiVA.org:uu-489445
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-799092 URI
024	7	a https://doi.org/10.1371/journal.pgen.10036072 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1271746992 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2066562 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4894452 URI
040		a (SwePub)umud (SwePub)kid (SwePub)uud (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ahmad, Shafqat4 aut
245	1 0	a Gene x physical activity interactions in obesity :b combined analysis of 111,421 individuals of European ancestry
264		c 2013-07-25
264	1	b Public Library of Science,c 2013
338		a electronic2 rdacarrier
520		a Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. Physical activity was assessed using self-administered questionnaires. Multiplicative interactions between the GRS and physical activity on BMI were tested in linear and logistic regression models in each cohort, with adjustment for age, age(2), sex, study center (for multicenter studies), and the marginal terms for physical activity and the GRS. These results were combined using meta-analysis weighted by cohort sample size. The meta-analysis yielded a statistically significant GRS x physical activity interaction effect estimate (P-interaction = 0.015). However, a statistically significant interaction effect was only apparent in North American cohorts (n = 39,810, P-interaction = 0.014 vs. n = 71,611, P-interaction = 0.275 for Europeans). In secondary analyses, both the FTO rs1121980 (P-interaction = 0.003) and the SEC16B rs10913469 (P-interaction = 0.025) variants showed evidence of SNP x physical activity interactions. This meta-analysis of 111,421 individuals provides further support for an interaction between physical activity and a GRS in obesity disposition, although these findings hinge on the inclusion of cohorts from North America, indicating that these results are either population-specific or non-causal.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Rukh, Gull4 aut
700	1	a Varga, Tibor V4 aut
700	1	a Ali, Ashfaqu Karolinska Institutet4 aut
700	1	a Kurbasic, Azra4 aut
700	1	a Shungin, Dmitryu Umeå universitet,Medicin,Institutionen för odontologi,Lund University4 aut0 (Swepub:umu)dmsh0003
700	1	a Ericson, Ulrika4 aut
700	1	a Koivula, Robert W4 aut
700	1	a Chu, Audrey Y4 aut
700	1	a Rose, Lynda M4 aut
700	1	a Ganna, Andrea4 aut
700	1	a Qi, Qibin4 aut
700	1	a Stancakova, Alena4 aut
700	1	a Sandholt, Camilla H4 aut
700	1	a Elks, Cathy E4 aut
700	1	a Curhan, Gary4 aut
700	1	a Jensen, Majken K4 aut
700	1	a Tamimi, Rulla M4 aut
700	1	a Allin, Kristine H4 aut
700	1	a Jorgensen, Torben4 aut
700	1	a Brage, Soren4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Aadahl, Mette4 aut
700	1	a Grarup, Niels4 aut
700	1	a Linneberg, Allan4 aut
700	1	a Pare, Guillaume4 aut
700	1	a Magnusson, Patrik KEu Karolinska Institutet4 aut
700	1	a Pedersen, Nancy Lu Karolinska Institutet4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Hamsten, Anders4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Pasquale, Louis T4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Scott, Robert A4 aut
700	1	a Ridker, Paul M4 aut
700	1	a Ingelsson, Eriku Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
700	1	a Laakso, Markku4 aut
700	1	a Hansen, Torben4 aut
700	1	a Qi, Lu4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Chasman, Daniel I4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001
700	1	a Hu, Frank B4 aut
700	1	a Renström, Frida4 aut
700	1	a Orho-Melander, Marju4 aut
700	1	a Franks, Paul W.u Umeå universitet,Medicin,Lund University and Harvard University4 aut0 (Swepub:umu)pafr0003
710	2	a Karolinska Institutetb Medicin4 org
773	0	t PLOS Geneticsd : Public Library of Scienceg 9:7, s. e1003607-q 9:7<e1003607-x 1553-7390x 1553-7404
856	4	u https://doi.org/10.1371/journal.pgen.1003607y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:645617/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003607&type=printable
856	4	u https://uu.diva-portal.org/smash/get/diva2:645146/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79909
856	4 8	u https://doi.org/10.1371/journal.pgen.1003607
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127174699
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206656
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489445

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By the author/editor: Ahmad, Shafqat; Rukh, Gull; Varga, Tibor V; Ali, Ashfaq; Kurbasic, Azra; Shungin, Dmitry; show more...; Ericson, Ulrika; Koivula, Robert ...; Chu, Audrey Y; Rose, Lynda M; Ganna, Andrea; Qi, Qibin; Stancakova, Alen ...; Sandholt, Camill ...; Elks, Cathy E; Curhan, Gary; Jensen, Majken K; Tamimi, Rulla M; Allin, Kristine ...; Jorgensen, Torbe ...; Brage, Soren; Langenberg, Clau ...; Aadahl, Mette; Grarup, Niels; Linneberg, Allan; Pare, Guillaume; Magnusson, Patri ...; Pedersen, Nancy ...; Boehnke, Michael; Hamsten, Anders; Mohlke, Karen L; Pasquale, Louis ...; Pedersen, Oluf; Scott, Robert A; Ridker, Paul M; Ingelsson, Erik; Laakso, Markku; Hansen, Torben; Qi, Lu; Wareham, Nichola ...; Chasman, Daniel ...; Hallmans, Göran; Hu, Frank B; Renström, Frida; Orho-Melander, M ...; Franks, Paul W.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: PLOS Genetics

By the university: Umeå University; Karolinska Institutet; Uppsala University

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